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10 Cards in this Set
- Front
- Back
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Hit |
Molecule that has potential to become a lead compound |
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Types of Scaffolds |
Can be linear, cyclic, or peptide framework |
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Privileged Scaffolds |
A molecular framework that can serve as a scaffold for a diverse number of targets |
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Types of Privileged Scaffolds |
These can be spider-like or have tadpole design |
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Disadvantages of Privileged Scaffolds |
1. Limits innovation 2. Inherently promiscuous |
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Advantages of Peptide Scaffold |
1. Easy to synthesize 2. Rapid diversity May not be orally available if larger than 500Da due to fast metabolism |
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Spider-like (cyclic) scaffold |
This type of scaffold is used to target pharmacodynamic properties |
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Click Chemistry |
This type of chemistry approaches the perfect synthesis. Cheap Very high yielding Specific Low toxicity Easily purified |
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Chemical space |
Describes structural diversity and the possible number of structures that could be synthesized |
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Epitopes |
Small molecules involved in fragment-based lead discovery that interact with a target binding site |
