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5 Cards in this Set
- Front
- Back
Enymatic drug inactivation
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1) All Beta-lactams (lactamases).
2) Aminoglycosides (acetylation). 3) Chloramphenicol (acetylation). 4) Streptogramins (lactonases). |
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Mutated drug receptor
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1) Fluoroquinolones.
2) Metronidazole. 3) Sulfonamides & Trimethoprim. 4) Penicillins (e.g. MRSA). 5) Aminoglycosides. 6) Streptogramins. 7) Linezolid. |
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Decreased Membrane Permeability to Drug
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1) Penicillins (porins).
2) Tetracyclines (efflux pump). (Tigecycline less sensitive.) 3) Macrolides (efflux pump). (Ketolides less sensitive.) |
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Ribosomal Methylation
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1) Clindamycin
2) Macrolides (ketolides less sensitive) 3) Streptogramins |
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Expression of Ribosomal Protection Proteins
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1) Tetracyclines (tigecycline less sensitive).
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