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17 Cards in this Set
- Front
- Back
Most Common form of arthritis
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OA
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As __ progresses, crystals of calcium phosphate are shed into the joint fluid and are commonly found in
severe __ |
OA
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PATHOLOGY OA
Gross Level |
- first see cartilage irregularities and splitting.
- next see ulceration of cartilage and frank cartilage loss - next, bone-on-bone contact then eburnation (polished bone) |
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PATHOLOGY OA
Microscopic Level |
- see fibrillation of cartilage
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Inflamation in OA
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Inflammation is not a significant component of OA. it is not considered an inflammatory condition or disease.
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OA PATHOLOGY
biochemically |
-decreased glycosaminoglycan content of cartilage including
less keratan less hyaluronic acid less chondroitin sulfate |
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Though __ parallels age, it is not considered a NL feature of aging
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OA
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Develops routinely in people whose occupations cause repetitive stress/trauma/impact to one or more joints
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OA
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Obesity increases risk for __, especially in the knees
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OA
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Most common joints affected in OA
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lumbosacral spine
hips knees feet but also cervical spine and PIP and DIP joints |
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MMP
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Matrix Metalloproteinase
increased in OA play significant role in degradation of extracellular matrix of cartilage |
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OA is primarily a disease of the _____ _____ of joints.
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hyaline cartilage
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Pathogenic Theory of OA
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mechanical stress which > change in chondrocyte metabolism >
proteolytic enzyme production (MMPs) > disruption of cartilage matrix |
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As OA progresses, crystals of _______ _______ are shed into the joint fluid and are commonly found in
severe OA |
calcium phosphate
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Morning stiffness < 30 min is a common symptom of _____
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OA
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Gelling
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stiffness after short periods of rest
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Possible reasons for OA associated pain
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periostitis
subchondral microfractures osteophytes (synovial nerve ending irritation) muscle spasm synovial inflammation (by chem junk) |