Mechanisms Of Action

Front 1

Increases viral RNA mutation rate?

Back 1

Ribavirin

Front 2

Inhibits reverse transcriptase resulting in chain termination?

Back 2

Adefovir, Entecavir Lamivudine

Front 3

Inhibits reverse transcriptase (nucleoside reverse transcriptase inhibitors)

Back 3

Zidovudine, Stavudine, Didanosine, Emtricitabine, Lamivudine, Abacavir

Front 4

Inhibits reverse transcriptase (nucleotide reverse transcriptase inhibitors). Competes with dATP for access to reverse transcriptase.

Back 4

Tenofovir

Front 5

Inhibits reverse transcriptase by binding near the active site and inducing a conformational change that blocks enzyme activation. No activation required. (Non-nucleotide reverse transcriptase inhibitors)

Back 5

Efavirenz and Nevirapine

Front 6

Inhibits HIV aspartic protease enzyme. Blocks posttranslational packaging of essential viral protein products. Impairs viral replication and proliferation?

Back 6

Protease inhibitors that all end in -navir.

Front 7

Inhibits HIV fusion with outer membrane?

Back 7

Fusion inhibitors Enfuvirtide and Maraviroc

Front 8

HIV-1 integrase strand transfer inhibitor. Prevents viral DNA from integrating with host genome?

Back 8

Raltegravir

Front 9

Introduce alkyl groups into nucleophiles through the formation of covalent bonds?

Back 9

Alkylating agents - mechlorethamine, cyclophosphamide, carmustine, Lomustine, Semustine, streptozocin, Temozolomide, Dacarbazine.

Front 10

Platinates adjacent guanines?

Back 10

Cisplatin

Front 11

Competitive inhibitor of dihydrofolate reductase?

Back 11

Methotrexate

Front 12

Converted to FdUMP and inhibits thymidylate synthetase?

Back 12

5-FU

Front 13

Binds to DNA creating single strand breaks, which require topoisomerase II, also forms free radicals as its mechanism of toxicity?

Back 13

Doxorubicin and Daunorubicin

Front 14

Intercalation of DNA base pairs, single and double strand breaks?

Back 14

Bleomycin

Front 15

Intercalates with minor groove of DNA between guanine and cytosine. Interferes with DNA-dependent RNA polymerase?

Back 15

Dactinomycin

Front 16

Complexes with topoisomerase II and DNA, single strand breaks in DNA. G2 and S phase specific?

Back 16

Etoposide

Front 17

Inhibit tubular processes, especially those related to mitotic spindle formation?

Back 17

Antimitotics: Vincristine, Vinblastine, Paclitaxel, Docetaxel

Front 18

Binds CD20 on B cells and depletes the B cell?

Back 18

Rituximab

Front 19

Binds to HER2 oncogene?

Back 19

Trastuzumab

Front 20

Inhibits protein tyrosine kinase; inhibits proliferation and induces apoptosis?

Back 20

Imatinib