Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/20

Click to flip

20 Cards in this Set

  • Front
  • Back
Increases viral RNA mutation rate?
Ribavirin
Inhibits reverse transcriptase resulting in chain termination?
Adefovir, Entecavir Lamivudine
Inhibits reverse transcriptase (nucleoside reverse transcriptase inhibitors)
Zidovudine, Stavudine, Didanosine, Emtricitabine, Lamivudine, Abacavir
Inhibits reverse transcriptase (nucleotide reverse transcriptase inhibitors). Competes with dATP for access to reverse transcriptase.
Tenofovir
Inhibits reverse transcriptase by binding near the active site and inducing a conformational change that blocks enzyme activation. No activation required. (Non-nucleotide reverse transcriptase inhibitors)
Efavirenz and Nevirapine
Inhibits HIV aspartic protease enzyme. Blocks posttranslational packaging of essential viral protein products. Impairs viral replication and proliferation?
Protease inhibitors that all end in -navir.
Inhibits HIV fusion with outer membrane?
Fusion inhibitors Enfuvirtide and Maraviroc
HIV-1 integrase strand transfer inhibitor. Prevents viral DNA from integrating with host genome?
Raltegravir
Introduce alkyl groups into nucleophiles through the formation of covalent bonds?
Alkylating agents - mechlorethamine, cyclophosphamide, carmustine, Lomustine, Semustine, streptozocin, Temozolomide, Dacarbazine.
Platinates adjacent guanines?
Cisplatin
Competitive inhibitor of dihydrofolate reductase?
Methotrexate
Converted to FdUMP and inhibits thymidylate synthetase?
5-FU
Binds to DNA creating single strand breaks, which require topoisomerase II, also forms free radicals as its mechanism of toxicity?
Doxorubicin and Daunorubicin
Intercalation of DNA base pairs, single and double strand breaks?
Bleomycin
Intercalates with minor groove of DNA between guanine and cytosine. Interferes with DNA-dependent RNA polymerase?
Dactinomycin
Complexes with topoisomerase II and DNA, single strand breaks in DNA. G2 and S phase specific?
Etoposide
Inhibit tubular processes, especially those related to mitotic spindle formation?
Antimitotics: Vincristine, Vinblastine, Paclitaxel, Docetaxel
Binds CD20 on B cells and depletes the B cell?
Rituximab
Binds to HER2 oncogene?
Trastuzumab
Inhibits protein tyrosine kinase; inhibits proliferation and induces apoptosis?
Imatinib