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20 Cards in this Set
- Front
- Back
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What is osteoarthritis?
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Degenerative joint disease which results in degradation of ARTICULAR CARTILAGE and subchrondral bone
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What is the difference between primary and secondary OA?
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Primary = if caused by age
Secondary = if caused by an identifiable factor |
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Describe OA in terms of mechanical and biochemical factors?
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OA is a MECHANICALLY DRIVEN but BIOCHEMICALLY MEDIATED process
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What is the most important cytokine in OA?
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IL-1B
- sets off proteinases which cause cartilage destruction |
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Besides cartilage, what else is damaged in OA?
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Bone and synovium
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What is seen in terms of chondrocyte activity/numbers in OA?
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Increase in chondrocytes (hypertrophy) in order to fix the joint damage
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What is one of the main reasons why chondrocyte repair is not all that effective?
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Because cartilage is very dense, thus hard to migrate to site of injury
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What are fibrillations in OA?
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Tiny tears/damage
- Bone loses "smooth" appearance -Looks like fibers coming off bone |
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What are osteophytes?
Where are they usually seen? |
Bony outgrowths
Usually seen to the side of the joint |
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What is subchondral sclerosis?
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When the bone beneath the cartilage becomes thickened
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What is seen in the synovium in OA?
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1. Cartilage Fragments
2. Fibroblasts 3. Macrophages |
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In OA, when do you get pain?
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Get pain with use
Stiffness in the morning, but w/in 10 minutes gets better |
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Where are Bouchards and Heberdens nodes seen?
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Bouchards: PIP Joint
Heberdens: DIP joint |
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Which IP joint is more commonly affected in OA?
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DIP - recall: different that RA in which PIP is most commonly affected
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What other hand joint is often affected in OA?
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1st MCP joint (thumb)
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What is the difference between OA and RA in terms of cause of disease?
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OA: mechanically driven
RA: immune system attacking joint |
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What is the difference between OA and RA in terms of age of patients?
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OA: Old
RA: any age |
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What is the difference between OA and RA in terms of joint distribution?
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OA: DIPs --> feels "boney"
RA: MCP/PIP and wrist --> feels "squishey" |
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What is the difference between OA and RA in terms of organs affected?
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OA: ONLY joints
RA: multiple tissues (including joints) |
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How is OA treated?
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1. exercise to strengthen muscles around joint
2. Give Tylenol/NSAIDS 3. Surgery to repair abnormal process/replace joint |
