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11 Cards in this Set
- Front
- Back
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What is seronegative spondyloarthropathy?
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- Multisystem inflammatory disease that affects the spine, periperal joints, and periarticular structures
- extrarticular involvement with inflammation of eye, skin, nails, aorta |
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What does seronegative mean?
spondylitis? |
Seronegative - no antibodies (like in RA)
spondylitis - inflammatory arthritis of the spine |
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What MHC class is associated with seronegative spondyloarthropathy?
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MHC I: HLA-B27
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What are the 5 ways the seronegative spondyloarthropathy differs from RA?
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1. Common sites are spine, sacroiliac joints, large joints. NOT small joints
2. Arthritis NOT symmetric 3. No autoantibodies 4. Genetics: MHC I (not II as in RA) 5. More common in men |
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What is seen in spine in seronegative spondyloarthropathy?
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- Ossification of total anterior ligament
- Patient loses mobility/flexibility |
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What is reactive arthritis?
Follows what 2 conditions? |
Seronegative large joint arthritis following:
- urethritis/cervicitis (STDs) - Infectious diarrhea |
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What is enthesitis?
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Inflammation of tendon insertions
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What is axial arthritis?
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Sacroiliitis - inflammation of sacroiliac joint
Spondylitis - inflammation of spine |
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What is the treatment for ankylosing spondylitis?
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1. Exercise Programs
2. Chronic, regular use of NSAIDs 3. TNF blockade - ameliorates both axial arthritis and extraarticular manifestations |
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What condition is strongly associated with ankylosing spondylitis?
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GI inflammation
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How is it currently thought that HLA-B27 causes spondylitis?
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- HLA-B27 may homodimerize to form abnormal cell surface dimers
- These can be recognized by NK cells and CD4+ cells - Leads to inflammation - ALSO may homodimerize in ER, leads to unfolded protein response and inflammation |
