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17 Cards in this Set
- Front
- Back
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How do hematopoietic stem cells divide?
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1 daughter returns to SC pool
1 daughter begins to differentiate |
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What are important factors in Non-hematopoietic regulation of hematopoiesis?
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1. Environment such as fibroblasts, endothelial cells,etc
2. Activated T cells, monocytes amplify basal pathways during infection 3. Hematopoietic Growth Factors - CSF's, IL's |
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Where is Erythropoietin (EPO) made?
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Kidney
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What is EPO's function?
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Stimulates erythropoiesis
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What are the functions of G-CSF and GM-CSF
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Colony Stimulating Factors that stimulate proliferation of myeloid progenitor cells
- Speed differentiation to neutrophils - helps with recovery after bone marrow transplantation |
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What are the function of TPO (thrombopoietin) mimetic (Romiplostim & Eltrombopag)?
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- Stimulate megakaryocyte proliferation and differentiation
- Give rise in platelet counts |
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What is aplastic anemia?
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- Condition where bone marrow does not produce enough new cells to replenish blood cells
- Bone Marrow become Hypocellular |
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What are 4 important Pediatric or Inherited causes of bone marrow failure?
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1. Dyskeratosis Congenita
2. Schwachman Diamond Syndrome 3. Diamond Blackfan Anemia (DBA) 4. Familial Aplastic Anemia |
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What is the most important Acquired or adult cause of bone marrow failure?
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Paroxysmal Nocturnal Hemoglobinuria (PNH)
Recall: Important cause of Hemolytic Anemia |
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What are the 3 categories for clinical classification of Aplastic Anemia?
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1. Onset: Acute, Chronic, Congenital
2. Blood cells affected - Pancytopenia - Single Lineage - Bi-lineage 3. Site of BMF - Central - Peripheral (marrow normal but can't exit) - Maturational arrest |
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What is seen in Diamond Blackfan Anemia?
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Lack of RBC differentiation
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Dyskeratosis Congenita (DC) causes what?
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Pancytopenia
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What is the genetic cause of Dyskeratosis Congenita (DC)?
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Defect in telomere maintenance
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Fanconi Anemia (FA) causes what?
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Pancytopenia
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Schwachman Diamond Syndrome (SDS) causes what?
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Myeloid Cell cytopenia
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What does Severe Congenital Neutropenia cause?
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- Neutropenia
- Promyelocytic maturation arrest |
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What do all Inherited Bone Marrow Failure Syndromes' Pathways have in common?
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All pathways share activation of p53
- causes cell cycle arrest and/or senescence |
