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13 Cards in this Set
- Front
- Back
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What are the 2 categories of lymphomas?
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1. Hodkin Lymphoma
2. Non-Hodkin Lymphoma |
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What cell is characteristic of Hodkin Lymphoma?
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Reed-Sternberg Cell
- Bi-nucleated "owl" cell |
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What are the 3 clinical presentations of HL?
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1. Painless Lymphadenopathy
2. Constitutional Symptoms - fever, night sweats, weight loss 3. Infection (ie TB) |
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What is the pattern of spread for HL?
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- Orderly pattern that is predictable
- Continuous, won't jump head --> Leg |
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What cell type is HL derived from?
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Germinal Center B Cell
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What does the Reed-Sternberg cell produce that helps create HL?
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- A cytokine soup
- IL-13 very important player |
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What are the 2 types of HL?
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1. Classical HL
2. Nodular Lymphocytic Predominant HL |
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What is the difference in growth pattern between CHL and NLPHL?
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CHL = diffuse or nodular
NLPHL = nodular |
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What is the main immunophenotype difference between CHL and NLPHL?
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NLPHL has CD20+, retains B cell antigen
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Macroscopically, what gives an easy diagnosis of HL?
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Nodular Sclerosis
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In HL, what is more important, Staging or Classification?
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STAGING
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What are the descriptors of the following stages of HL?
Stage 1: Stage 2: Stage 3: Stage 4: |
Stage 1: One region
Stage 2: 2 regions (one side of diaphragm) Stage 3: Both sides of Diaphragm Stage 4: Disseminated beyond the lymphatic system |
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What is the overall 5 year survival of HL?
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>81%
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