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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Responses to the extracellular environment involve cell membrane or intracellular receptors whose engagement modulates cellular components that:
- generate, -amplify, -coordinate -terminate postreceptor signaling via = |
(cytoplasmic) second messengers.
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Transmembrane signaling is accomplished by only a few mechanisms:
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- G-protein-coupled receptors:
- Kinase-linked receptors: - ion channels (Transmembrane-ion): - Nuclear receptors |
G
K I N |
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Transmembrane ion channels:
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-open or close upon binding of a ligand
or - upon membrane depolarization |
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-open or close upon binding of a ligand
or - upon membrane depolarization Type of channel = |
Transmembrane ion channels:
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G-protein-coupled receptors:
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-Transmembrane receptor protein
stimulates a GTP-binding signal transducer protein (G-protein) ..... which in turn generates an intracellular second messenger |
GTP-binding signal transducer protein = (G-protein)
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stimulates a GTP-binding signal transducer protein (G-protein) .....
which in turn generates an intracellular second messenger Type of channel = |
G-protein-coupled receptors:
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Nuclear receptors
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-Lipid soluble ligands
that cross the cell membrane and act on an intracellular receptor |
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-Lipid soluble ligands
that cross the cell membrane and act on an intracellular receptor Type of channel = |
Nuclear receptors
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Kinase-linked receptors:
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-Transmembrane receptor proteins
with intrinsic or associated kinase activity which is allosterically regulated by a ligand that binds to the receptor’s = |
extracellular domain
allosterically (defined) -binds a compound on an inactive site and thus changes conformation in order to become either active or inactive |
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-Transmembrane receptor proteins
with intrinsic or associated kinase activity which is allosterically regulated by a ligand that binds to the receptor’s Type of channel = |
Kinase-linked receptors:
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G-Proteins:
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-Guanine nucleotide binding proteins: =
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participate in reversible, GTP-mediated interactions.
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