Md2 Block1 7 Neurotransmitters 2 Part A

Front 1

All monoamine (MA) neurotransmitters are synthesized from _____ acids through a series of enzyme catalyzed reactions in which ____________, decarboxylation and/or ___________ convert the precursor amino acid into the active monoamine neurotransmitter.

Back 1

amino

hydroxylation & or methylation

Front 2

__________ projects to almost every area of the brain.

Back 2

NE

Front 3

_____ & ______ have more restricted projections. in the brain

Back 3

DA and E

Front 4

DA and E have more restricted projections.

Back 4

Generally, the cell bodies of catecholamine neurons are found in clusters in the brain stem or midbrain and project to other regions of the brain and spinal cord.
NE projects to almost every area of the brain. In contrast, DA and E have more restricted projections.

Front 5

Monoamine transporters(are protein structures that function as integral plasma membrane transporters to regulate concentrations of extracellular MA)

Back 5

Monoamine transporters - role in reuptake of the monoamines dopamine, noradrenaline, and 5-hydroxytryptamine. They are factors in several neurological conditions:depression,drug abuse, Parkinson disease, Schisophrenia, Tourette syndrome

Hint 5

Front 6

High level of catecholamine may be cause of

Back 6

hypertensive crisis and
Serotonin syndrome

Front 7

hypertensive crisis and
Serotonin syndrome may be caused from =

Back 7

catecholamine

Front 8

catecholamine
high concentration have presynaptic amphetamine like effect on Monoamine release
catecholamine

Back 8

(Serotonin and Dopamin)

Front 9

Monoamines are neurotransmitters and modulators that contain

Back 9

one amino group

Front 10

Monoamines are neurotransmitters
Derived from

Back 10

amino acids

Nm them =
5ct

Hint 10

Histamine
phenylalanine
thyroid hormones
tyrosine
tryptophan

Front 11

Derived from

Back 11

Monoamines are neurotransmitters

Front 12

Catecholamines
Derived from

Back 12

:Dopamine
Noradrenaline
Adrenaline(Epinephrine

Front 13

Tryptamines
Derived from

Back 13

Melatonin
Serotonin

Front 14

Trace amines
Derived from

Back 14

beta phenylethylamine –PEA
Tyramine
Tryptamine

Front 15

adrenergic receptors are a class of

Back 15

metabotropic
G protein-coupled receptors

Front 16

metabotropic
G protein-coupled receptors
are what class

Back 16

adrenergic receptors

Front 17

adrenergic receptors
Alfa receptor

Back 17

activation (excitation)=

ie:
2ct

Hint 17

vasoconstriction
and pupillary dilatation

Front 18

adrenergic receptors
Beta receptors

Back 18

predominantly inhibitory =

Hint 18

bronchial dilation,
Decrease gastrointestinal motility,

Front 19

Serotonin
With the exception of the 5-HT3 is ligand gated ion channel, all other serotonin receptors are metabotropic G protein coupled receptors that activate an intracellular second messenger to produce an excitatory or inhibitory response.

Back 19

.

Front 20

Serotonin receptor exception

Back 20

5-HT3 is _____ gated ion channel, all other serotonin receptors are __________ ______________ _____________ intracellular second messenger to produce an excitatory or inhibitory response.

Hint 20

ligand

Front 21

Serotonin
With the exception of the 5-HT3 is ligand gated ion channel, all other serotonin receptors are metabotropic G protein coupled receptors that activate an intracellular second messenger to produce an excitatory or

Back 21

Dopamin receptors:metabotropic G protein coupled receptors (Dopamin is ligsnd for them) Dysfunction of dopaminergic neurotransmission in the CNS has been implicated in a variety of neuropsychiatric disorders