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5 Cards in this Set
- Front
- Back
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Define secretory vs. endocytic pathway
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secretory pathway-outward, proteins synthesized on ER membrane are delivered to the cell surface or lysosomes via the Golgi apparatus and in some cases secretory vesicles; provides for delivery of newly synthesized proteins and carbs to the cell exterior
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compare and contrast clathrin vs COP coated vesicles in terms of their structure, assembly and disassembly
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Clathrin- transports between Golgi and lysosome, Golgi to secretory vesicles and plasma membrane to endosomes
COP-ER and Golgi, Golgi and cisternae clathrin- disassembles quickly COP- disassembles upon reaching target clathrin- assembled with adaptins and dynamin COP-monomeric G proteinsGTP-binding with GTPase activity controlled by two proteins- GEF and GAP |
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describe the roles of SNAREs, Rabs, NSF and dynamin in vesicular transport
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SNAREv for vesicle, SNAREt for target
Rabs recognized and captured by tethering proteins on target SNARE docks, NSF ATPase then disassembles so SNARES can be recycled |
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describe the structure and function of the Golgi apparatus
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has cis face and trans face, cis face toward nucleus, stacks of citernae
carb synthesis, modification of N-linked oligosaccharide chaings on glycoproteins made in ER, generation of glycosaminoglycan chains on core proteins of proteoglycans, sorting and dispatching of ER products |
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compare and contrast constitutive vs. regulated exocytosis pathways
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constitutive- just goes to plasma membrane exits the cell if no signal
regulated- found in specialized secretory cells- proteins are diverted into secretory vesicles to bud off trans golgi, release their contents only in response to an extracellular signal |
