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4 Cards in this Set
- Front
- Back
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4 Mechanisms to Repair DNA
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- Base excision repair
- Nucleotide excision repair - Homologous recombiation, non-homologous end joining - Mismatch repair |
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What do HNPCC, HBOC, XP. All have in common?
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Diseases that are associated with loss of DNA repair Mechanisms!
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Error-prone DNA repair Mechanisms (2)
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Non-homologous end joining
Translesion synthesis (Damage on one strand of the DNA while copying), makes up the sequence because template strand is unreadable. |
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Error-free DNA repair Mechanisms (mostly, 2)
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Excision and resynthesis; damage on one strand and use the other to repair, mismatches.
Homologous recombination: find another copy of the damaged sequence and use that to fill in the lost information. |
