Mcb130

Front 1

Cytochalasin B

Back 1

Bind to + end prevents elongation
- shrinks to Cc-
- doesn't affect muscle

Cap Z

Front 2

Phalloidin

Back 2

binds at interface between subunits, prevents depolymerization

- stabilizes
- change rates at both ends
- ATP hydrolysis irrelevant

-tropomyosin

Front 3

Latrunculin

Back 3

sequesters, changes the shape


- thymosin b4

Front 4

thymosin B4

Back 4

sequesters, binds to ADP form


- latrunculin

Front 5

Profilin

Back 5

sequesters, promote poly at + end

- exchanges ATP for ADP
- promotes binding to + end with high affinity

Front 6

Cofilin (ADF)

Back 6

promotes dissembly at -


- bound middle causes stress and severing

Front 7

LIM Kinase

Back 7

phosphorlyates ADF and promotes function

Front 8

PIPII

Back 8

binds ADF and profilin and inactivates them

Front 9

VASP

Back 9

bind profilin and localizes them

Front 10

Tropomodulin

Back 10

capper at - end

Front 11

Cap Z

Back 11

capper at + end


- cytochalsin B

Front 12

Tropomyosin

Back 12

stabilizes actin in muscle

- phalloidin

Front 13

ARP 2/3

Back 13

template at - end, outgrowth

- regulated by WASP, needed to activate

Front 14

Formins

Back 14

nucleator, + end and promote addition of new subunits

-prevents capping
- poly at + end

Front 15

Fimbrin

Back 15

Cross link, two ABD and spacer

- stiff bundles
- calmodulin subunit binds ca2+, activates

Front 16

Filamin

Back 16

Mesh work, cross linker, more floppy
-calmodulin unit

Front 17

Gelsolin

Back 17

cuts crosslnks, binds + end


- ADF

Front 18

a- actinin

Back 18

semi-stif bundles, dimer, tails interact can wilgge alittle bit but not as much as filamin

Front 19

Titin

Back 19

spring that holds the myosine

Front 20

nebulin

Back 20

molecular ruler, binds to actin and wraps along entire thin filament

Front 21

Troponin Complex

Back 21

binds tropomyosin, 3 subunits, TIC

- as CA2+ rises, triggers shape change in troponin, causes tropomyosine to move and allows myosine to bind