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15 Cards in this Set

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Where is HMP active?
-In tissues that regularly synthesize steroids or fatty acids.
-eg. mammary tissue, liver, adrenal glands.
Fxn's of NADPH?
-Pyridine nucleotide used for reductive biosynthesis.
-Maintain proper glutathione levels.
-VERY ACTIVE IN RBC's.
Need for Ribose-5-phosphate?
-For biosynthesis of ribonucleotides and derivatives.
Iron Hemoglobin maintained in reduced form (Fe++) through?
-Action of methemoglobin reductase which requires NADH.... NOT NADPH.
What are the 2 sections of HMP?
-Oxidative(regulated part)

-Non-oxidative.
Describe the oxidative pathway?
-3 rxn's.
-All allosterically controled by NADPH
-From glucose-6-phosphate to ribulose-5-phosphate, CO2 and 2 NADPH.
-ALL INTERMEDIATES ARE PHOSPHORLYATED.
Rxn 1 of oxidative pathway?
- Glucose-6-phosphate--> 6-phosphocluconolactone.
- 1 NADPH(Inhibited by)
- Via GLUCOSE-6-PHOSPHATE DEHYGROGENASE
Rxn 2 of oxidative pathway?
- 6-phosphocluconolactone --> 6-Phosphogluconate
- H2O-->H+
- Via Gluconolactonase
Rxn 3 of oxidative pathway?
- 6-Phosphogluconate --> Ribulose-5-Phosphate (first pentose formed)
- 1 NADPH(Inhibited by)& CO2
- Via 6-phosph-gluconate dehydrogenase.
Non-oxidative pathway consists of?
- Near equilibrium rxns.
- Transketolase's
- Transaldolase's
- Convert Pentose to 3,4,6,7 -carbon sugar phosphates
Action of Transketolases?
***TRANSFER OF 2 CARBON SUGAR***
- Eg. Convert from 5,5 to 3 & 7 sugar phosphate.
- REQUIRES TTP
What is TPP?
- Thiamin pyrophosphate
- Covalently bound to enzyme via Schiff Base. (Lysine residue)
- Required by TransKetolases.
*********Does the phosphate group move throughout the pathway?********
- NO, the phosphate does not move. The group that bares the phosphate actually moves.
Action of Transaldolases?
***TRANSFER OF 3 CARBON SUGAR***
- Eg. 7,3 to 4,6
What are the 2 fates of Rubulose-5-phosphate? Via?
- Xylulose-5-phosphate via Epimerization
- Ribose-5-phosphate via Isomerization