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12 Cards in this Set
- Front
- Back
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Nuclear Envelope
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Double lipid bilayer:
Outer membrane directly connected to rER Perinuclear space- continuous with ER Cytoplasmic side supported by intermediate filaments (cytoplasmic IFs) & studded with ribosomes Inner membrane supported by nuclear lamina (lamin IFs) Nuclear pore complexes (NPC) |
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Nucleoporins
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glycoproteins of NPC
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Importin
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Cargo protein contains Nuclear
Localisation Signal (NLS) |
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Exportin (export receptors in nucleus) binds NES & nucleoporins: Exports
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Cargo protein contains Nuclear
Export Signal (NES) |
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Translocation of protein complexes through NPC requires energy
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(from hydrolysis of GTP : mediated by Ran GTPase )
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Nuclear Envelope
|
Double lipid bilayer:
Outer membrane directly connected to rER Perinuclear space- continuous with ER Cytoplasmic side supported by intermediate filaments (cytoplasmic IFs) & studded with ribosomes Inner membrane supported by nuclear lamina (lamin IFs) Nuclear pore complexes (NPC) |
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Nucleoporins
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glycoproteins of NPC
|
|
|
Importin
|
Cargo protein contains Nuclear
Localisation Signal (NLS) |
|
|
Exportin (export receptors in nucleus) binds NES & nucleoporins: Exports
|
Cargo protein contains Nuclear
Export Signal (NES) |
|
|
Translocation of protein complexes through NPC requires energy
|
(from hydrolysis of GTP : mediated by Ran GTPase )
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GAPs hydrolyse GTP
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Switched “Off”, bound to GDP
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GEFs exchange GDP for GTP)
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Turned “On” by binding GTP
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