Mbbs Gi Pharmacology L27 - Antibacterial Treatment Of Enteric Infections

Front 1

Tetracyclines
uses 2

Back 1

broad spectrum
due to resistance not for common bacterial infection

Front 2

Tetracyclines
adverse effects 5

Back 2

1. local tissues irritation
2. avoid in pregnancy (cross the placenta and affect the fetal growth, liver toxicity)
3. hepatotoxicity
4. teeth discoloration
5. GI irritation (upset the normal flora)
6. vestibular system (dizziness)
7. photo-sensitization (abnormal sun burnt)

Front 3

tetracyclines
example:
Doxycycline advantages list three.

Back 3

longer duration of action
absorption is not greatly reduced upon meal
excreted in bile and not accumulate in kidney = can b e used in renal patients

Front 4

tetracyclines example
Glycylcyclines

when to use? 2
excretion 1

Back 4

for multi-resistance Gram + bacteria
indicated for treatment of complicated skin & soft tissue infections as well
as complicated intra-abdominal infections

eliminated via biliary excretion

(not effective vs. Proteus & Pseudomonas spp)

Front 5

Inhibition of bacterial folic acid synthesis
antifolates

Back 5

Sulphonamides
– inhibit dihydropteroate synthetase

Trimethoprim
– inhibits dihydrofolate reductase

Front 6

Cotrimoxazole
what is that?

Back 6

Sulphonamides + Trimethoprim (5:1)

Front 7

adverse effects of Cotrimoxazole

Back 7

1 GI discomfort (nausea, vomiting, diarrhoea)
2 hypersensitivity reactions (allergic reactions)
3 urinary tract disturbances (crystalluria, hematuria or obstruction)
4 hematopoietic (anemia, granulocytopenia)