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18 Cards in this Set
- Front
- Back
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Cancer related to Hepatitis B virus
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Primary hepatocellular virus
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HBV genes & what they encode
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C gene (core protein & serum e Ag), S gene (3 related surface Ag translated from diff start codons), P gene (viral DNA poly), & X gene (non-structural protein)
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Mech of HBV
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Binds & inactivates cellular growth reg (eg p53). Activates ras-rafMAP kinase & NF-kb. Binds TF, DNA repair protein (UV-DDB), & contributes to development of hepatocellular carcinoma.
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Cancer related to Human herpes virus 8
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Kaposi sarcoma, Castlemann's disease, Pleural B-cell lymphoma, & other AIDS diseases
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Mech of Human herpesvirus 8
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Expresses homolog of IL-6-> promotes growth if IL6 dependent cell lines, activates signaling pathways (jak/stat & Ras-MAP), & is a potent inducer of VEGF
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Charac of papillomavirus
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Naked, icosahedral symmetry, circ double-stranded DNA, early genes E1-E5, E6/E7 are oncogenes, late genes L1 & L2 express viral capsid protiens
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Mech of papillomavirus
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E6 inactivates p53 & E7 inactivates Rb
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Pathogenesis of papillomavirus
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Contagious, transmitted via direct contact through breaks in the skin or mucus membranes, localized latent or persistent infection of basal epithelium. (over 130 types)
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Benign HPV diseases
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Common warts (HPV 1-4), Epidermodysplasia verruciformis (rare AR trait w/ depressed immunity- HPV 5 & 8), Recurrent respir pap (HPV 6 & 11- laryngeal tumus in childhood), Chondyloma (HPV 6 & 11- STD)
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Malignant HPV diseases
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Cervical cancer (HPV 16 squa cell, 18 adenocarcinoma, 31, 33, 45). Most common cancer of women in devel countries
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2 types of lesions caused by persistent infection of HPV
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squamous intraepi lesion(SIL) & cervical intraepi neoplasia (CIN). Low grade SIL= CIN 1-> not treated. High grade SIL=CIN2/3-> surgery (LEEP)
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Charac of HPV vaccine. 2 types
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Synthetic virus-like particle containing the L1 capsid. Gardasil (Merck) HPV 6, 11, 16, 18 w/ alumminum adjuvant. Cervarix (GSK) HPV 16, 18 w/ alumm & TLR4 agonist.Some cross protection for HPV 31 & 45
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Cancers caused by epstein-Barr virus
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Burkitts lymphoma (african endemic), Nasopharyngeal carcinoma, Hodgkin's, t-cell lymphoma, AIDS-related lymphoma, post-transplant lymphoprolif disorder
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Mech of EBV infection of B cells
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gp350 binds CD21 on B-cells. Entry via cmplx of 3 viral proteins (gH, gL, & gp42). Gp42 binds MHC II.
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How does EBV transform B-cells
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EBNA 1,2,3,5,6 & LMP1 genes are essential for immortalization. EBNA2 & LMP1 are oncogenes
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Fcn of EBNA2
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Doesn't bind DNA but interacts w/ TF. TrnsactivatesCD21, 23, c-fgr & **c-myc oncogene. Also targets Cp promtor to drive expression of EBNA & LMP genes
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Fcn of LMP1
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Mimics the role of CD40 in B-cell activation-> activates NF-kb, AP1, & STAT mediatd transcription through TRAF, TRADD, & JAK3. Constitutive activation (no ligand required)
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Gene expresion in malignant disease
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Burkitts= EBNA 1 only (Latency I). Other EBNA diseases= EBNA1, LMP1/2. Post-transplant lymphoprolif disorders express all latency genes (Latency III)
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