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11 Cards in this Set
- Front
- Back
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Most folate in food is polyglutamate. In the GI, these enzymes remove glutamate to enhance folate absorption
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conjugases
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Methotrexate (an analog of folate) is a competitive inhibitor of what enzyme?
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dihydrofolate reductase (key enzyme in pyrimidine synthesis)
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Result of folate deficiency
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Megaloblastic/macrocytic anemia
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Possible outcomes of maternal deficiency of folate.
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Spina bifida
Anencephaly |
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Symptoms of folate deficiency
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Inflammation of tongue and mouth
Abnormal skin pigmentation Weakness Fatigue Diarrhea Poor growth Depression Mental confusion |
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B12 is synthesized exclusively by:
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Bacteria
Fungi Algae |
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Location at which the intrinsic factor/B12 complex is absorbed
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ileum
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B12 is required as a coenzyme in what two conversion reactions?
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Methylmalonyl CoA --> succinyl CoA
Homosystine --> Met |
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Symptoms of B12 deficiency
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Sensory disturbances in legs
Paresthesia Loss of concentration Visual disturbances Disorientation Dementia Sore tongue Loss of bowel and bladder control |
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Primary methyl donor for many important reactions that relies on Met
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S-Adenosylmethionine (SAM)
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Deficiency in either folate or vitamin B12 results in:
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Megaloblastic anemia
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