Mayo_Mm Nonvolatile Anesthetic Agents

Front 1

Etomidate - Mechanism

Back 1

depresses the reticular activating system and mimics the inhibitory effects of GABA

Front 2

Etomidate - Absorption

Back 2

available only for intravenous administration.

Etomidate is dissolved in propylene glycol. This solution often causes pain on injection that can be lessened by a prior injection of lidocaine.

Front 3

Etomidate - Organ Effects (Cardiac)

Back 3

minimal effects on the cardiovascular system. A mild reduction in peripheral vascular resistance is responsible for a slight decline in arterial blood pressure. Myocardial contractility and cardiac output are usually unchanged. Etomidate does not release histamine.

Front 4

Etomidate - Dosing

Back 4

Induction = 0.3 mg/kg

Cardioversion/sedation = 0.2 mg/kg

Front 5

Etomidate - Drug interactions

Back 5

Fentanyl increases the plasma level and prolongs the elimination half-life of etomidate.

Opioids decrease the myoclonus characteristic of an etomidate induction.

Front 6

Etomidate - Organ Effects (Neuro)

Back 6

may have disinhibitory effects on the parts of the nervous system that control extrapyramidal motor activity. This disinhibition is responsible for a 30–60% incidence of myoclonus.

decreases the cerebral metabolic rate, cerebral blood flow, and intracranial pressure to the same extent as thiopental.

nausea & vomiting are common

Front 7

Etomidate - Organ Effects (Respiratory)

Back 7

Ventilation is affected less with etomidate than with barbiturates or benzodiazepines.

Front 8

Etomidate - Organ Effects (Endocrine)

Back 8

Induction doses of etomidate transiently inhibit enzymes involved in cortisol and aldosterone synthesis. Long-term infusions lead to adrenocortical suppression that may be associated with an increased mortality rate in critically ill patients.