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11 Cards in this Set
- Front
- Back
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increased extracellular osmolarity (NaCl) stimulates ____ release
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ADH
which increases H2O reabsorption, and stimulates thirst (intake of water) |
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ADH synthesis in the _____-cellular neurons of hypothalamus, release by the posterior pituitary, and has action on the kidneys
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magnocellular
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Treatment for central DM
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desmopressin
(ADH analog) |
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Treatment for nephrogenic DM
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low-Na diet
increase fluid intake thiazide diuretic (for Na secretion) |
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Stimuli for ADH Secretion
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Increased osmolarity
Decreased blood volume (cardiopulmonary reflexes) Decreased blood pressure (arterial baroreceptors) - input from cerebral cortex (e.g. fear) - angiotensin II ? - nausea - nicotine - morphine |
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Which is the mroe powerful stumulant of ADH,
a) osmolarity b) volume decrease |
osmolarity
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Factors that Decrease ADH Secretion
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Decreased osmolarity
Increased blood volume (cardiopulmonary reflexes) Increased blood pressure (arterial baroreceptors) Other factors: - alcohol - clonidine (α-2 adrenergic agonist) - haloperidol (antipsychotic, tics,Tourette’s) |
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Stimuli for Thirst
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Increased osmolarity
Decreased blood volume (cardiopulmonary reflexes) Decreased blood pressure (arterial baroreceptors) Increased angiotensin II Other stimuli: - dryness of mouth |
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Factors that Decrease Thirst
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Decreased osmolarity
Increased blood volume (cardiopulmonary reflexes) Increased blood pressure (arterial baroreceptors) Decreased angiotensin II Other stimuli: -Gastric distention |
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What is the Effect of changes in Na intake on plasma Na after blocking ADH-thirst system?
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The plasma Na concentration is not as tightly controlled
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Effect of changes in sodium intake on plasma sodium
after blocking aldosterone |
not much
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