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13 Cards in this Set

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Herpesvirus lesions in cetaceans?
1. life-threatening disseminated infections
2. non-life-threatening dermatitis.

Gross: hyperplasia, papules.
Histo: epithelial hyperplasia, INIB.

(personal note: wouldn't call it dermatitis based on the findings described)
JZWM vol37 issue 2 june 2006 pp.174-181
Novel gammaherpesvirus in Northern Elephant Seals:
Lesions?
Ulcers on the tongue, palatine mucosa, and/or tonsils.
Cytoplasmic swelling, nuclear pyknosis, and eo to ampho INIB suggestive of herpesviral infection.
JWD Goldstein et al (2006, I think)
Significance of hookworms in California sea lions?
Pups: "hookworm enteritis - bacteremia complex". Uncinaria spp.
Mid small intestine.
Associated lesions: peritonitis, polyarthritis, pleuritis, hepatitis, hematogenous pneumonia.
Histo: neu/eo/lym/plas
JWD 43(2) 2007 p.179
Eimeria phocae in harbour seals:
lesions?
Fatal enterocolitis.
Last 1/3 of jejunum, ileum, caecum, colon.
Hemorrhagic and necrotizing enterocolitis.
G.H. van Bolhuis et al.
Pathological findings in harbour seals Schleswig-Holstein:
1. which organ systems most commonly affected?
2. most common cause of death?
3. most frequently isolated bacteria?
4. which changes more frequent after 2002?
1. respiratory and alimentary.
2. bronchopneumonia by parasites and/or bacteria.
3. alpha/beta-hemolytic streptococi, E. coli, C. perfringens.
4. parasites in lung, stomach, intestine; bronchopneumonia, gastritis, enteritis, septicaemia, perinatal death.
JCP 2007 137 47-58
Lesions associated with a novel Mycoplasma sp. in california sea lions undergoing rehabilitation?
Pneumonia, polyarthritis, subdermal / intramuscular abscessation, lymphadenopathy.
JWD 42(1) 2006 40-45
Phocine herpesvirus 1:
lesions in European harbor seals?
Pneumonia
Hepatomegaly
Small erosions of the oral mucosa.
Micro: liver: severe to massive coagulation necrosis with no specific zonal pattern. Interstitial pneumonia with mononuclear infiltrates.
Diseases of pinnipeds lecture notes.
Endemic tumors in Californa sea lions:
cause?
lesions?
Otarine Herpesvirus-1 (NOT papillomavirus).
Urogenital carcinoma. Highly aggressive, anaplastic. In sexually mature (not elderly) sea lions.
JCP 2006 135(4) 183-9
Chronic stress in Atlantic bottlenose dolphin:
changes in adrenal gland?
- increase in adrenal mass
- increase in cortex to medulla ratio
- increase in epinephrine-producing cells within the medulla -> increased thickness medullary band.
JCP 2006 135 208-216
Marine mammal neoplasia:
1. name 2 species particularly prone to cancer; the common neoplasm and the (suspected) cause.
2. And in seals?
3. Manatees?
2. and
1. California sea lion (urogenital tract neoplasia, Otarine Herpesvirus 1, INIB!); St Lawrence region: beluga whales (possibly contaminants; GI cancers!).
repro.
2. genital tract; xenoestrogens.
3. skin; papillomavirus.
Vet Pathol 43:865-880 (2006)
Relationship between red tides and marine mammal mortalities?
Potent marine neurotoxins: brevetoxins, produced by 'red tide' dinoflagellate Karenia brevis.
Fish and seagrass accumulate toxin (vector) -> dolphins and manatees, respectively.
Nature 435 9 june 2005 p.755
Pathology of domoic acid in california sea lions?
DA = neurotoxic, analog of excitatory neurotransmitter L-glutamate. Produced by marine algae. Vectors: algivorous / filter feeding spp. (here: anchovy). -> seizures, obtundation.
Gross: piriform lobe malacia, myocardial pallor, bronchopneumonia, pregnancy complications.
Peracute: hydropic degeneration neuropil hippocampus/amygdala/pyriform lobe.
Acute-> ischemic neuronal necrosis (dentate gyrus)
Chronic-> gliosis, mild nonsupp infl, loss of laminar organization.
Peracute ->
Vet Pathol 42:184-191 (2005)
Amazon and orinoco river dolphins:
Most common pathologic findings?
High mortality in first 2 months after capture and transport for relocation.
1. pneumonia 42%
2. cutaneous and SQ ulcerations and abscesses 36%
3. cachexia
4. renal pathology
5. hepatic pathology
6. bacterial sepsis
- often pulmonary trematodes (Hunterotrema caballeroi) predisposing to pneumonia
- pneumonia was generally bacterial
- abscesses: "golf ball disease"
- cetaceans are unusually prone to bacterial septicemia
- prevalent gastric ulceration
JZWM 38(2):177-191 2007