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13 Cards in this Set
- Front
- Back
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What types of cells are located in the Fundus and Body?
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Chief Cells (pepsinogen)
Mucous Glands Parietal Cells (HCl) |
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What types of cells are located in the antrum and pyloric part of the stomach?
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G Cells (gastrin)
D Cells (somatostatin) |
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Defensive Factors fighting gastroduodenal damage
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Bicarbonate
Mucus prostaglandins GF's |
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How do NSAIDs, smoking, and booze lead to Ulcers
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1. Disturb the defenses-->GU
2. Lead to an increased Parietal Cell Mass--> Increase HCl--> DU |
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Manifestations of PU's
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1. Dyspepsia
2. Abd. Pain 3. Heartburn 4. Complications (bleeding, obst. perf) |
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Manifestations of GERD
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1. Dyspepsia
2. Dysphagia 3. Heartburn 4. Complications (laryngeal, dental, anemia, Barrett) |
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Tests for PU
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Barium
Endoscopy Tests for H. PYlori |
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Tests for GERD
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Barium
Nuclear Scan test 24hr pH test Bernstein Test Endoscopy |
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Types of drugs used to combat PU and GERD
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Antacids
Chelators (sucralfate) Prostaglandin Analogs (not for women of child-bearing age) H2-Receptor Antagonists PPI's |
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Drug interactions of the H2-receptor antagonists
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Cimetidine: increases the level of lots- booze, etc
decreases the level of others Ranitidine: increases level of warfarin, metformin, etc |
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Drug interactions of PPI's
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INcrease the level of: warfarin, diazepam, etc.
Decrease level of azoles |
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Rx. for GERD
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Exclude delayed gastric emptying
H2RA's in mild disease PPI's in severe disease |
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When do you take PPI's?
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20-30 minutes before meal
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