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21 Cards in this Set
- Front
- Back
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List the two main drugs used in TB treatment.
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1. Isoniazid
2. Rifampicin |
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List 'other' drugs used in TB treatment.
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1. Pyrazinamide
2. Ethionamide 3. Ethambutol 4. Streptomycin 5. Capremycin 6. Cycloserine 7. Fluirquinolones |
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What is the mechanism of action of Isoniazid ?
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It inhibits mycolic acid synthesis.
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What is the mechanism of action of Rifampicin ?
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It inhibits DNA-dependent RNA-polymerase.
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What are the adverse effects of using Isoniazid ?
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1. Peripheral neuropathy
2. Optic neuritis 3. Psychosis and seizures 4. Skin eruptions 5. Hepatitis 6. Idiosyncratic hepatotoxicity 7. Inhibits metabolism of Phenytoin |
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What are the adverse effects of using Rifampicin ?
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1. Skin eruptions
2. Fever 3. GI disturbances 4. Hepatitis 5. Flu-like 6. Drowsiness 7. Headache 8. Mental confusion 9. Muscular weakness 10. Induces liver metabolic enzymes 11. Inhibits contraceptives 12. Red appearance of sweat, tears and urine |
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List the different drugs used to treat malaria.
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1. Quinone
2. Choloquine 3. Mefloquine 4. Pyrimethamine 5. Proguanil 6. Primaquine 7. Atovaquone-proguanil 8. Artemisin |
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What is the mechanism of action of Quinone, Choloquine and Mefloquine ?
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It inhibits haem polymerase.
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What is the mechanism of action or Pyrimethamine and Proguanil ?
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It inhibits the dihydrofolate reductase enzyme.
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What are the therapeutic indications for using Quinone ?
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1. Eyrthrocitic forms of all plasmodia
2. P. falciparum |
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What are the therapeutic indications for using Choloquine ?
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1. Erythrocitic forms of all plasmodia
2. Gametocytes of vivax, ovale and malariae |
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What are the therapeutic indications for using Mefloquine ?
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1. Prophylaxis of malaria
2. Resistant falciparum |
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What are the therapeutic indications for using Pyrimethamine and Proguanil ?
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They are used for all the plasmodia.
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What are the therapeutic indications for using Primaquine ?
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Secondary tissue forms of vivax and ovale.
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What are the therapeutic indications for using Atovaquone-proguanil ?
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Resistant falciparum and vivax.
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What are the therapeutic indications for using Artemisinin ?
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Asexual erythrocytic stages of vivax and falciparum.
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What are the adverse effects of Quinone ?
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• GI disturbances
• Chinconsm • Hypotension • Cardiac dysrhythmias • Delirium • Coma |
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True or false: Choloquine is not safe to use during pregnancy.
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False. It is safe.
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True or false: Mefloquine is not safe to use during pregnancy.
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True.
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True or false: Pyrimethamine can cause methemglobinemia.
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False. This is true for Primaquine.
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True or false: Pyrimethamine can cause megaloblastic anemia.
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True.
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