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19 Cards in this Set
- Front
- Back
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Inhibitors of Protein Synthesis
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Corynebacterium diphtheriae +
Pseudomonas aeruginosa - Shigella dysenteriae - Enterohemorrhagic E.coli - |
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Neurotoxins
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Clostridium tetani -
Clostridium botulinum - |
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Superantigens
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Staphylococcus aureus +
Streptococcus pyogens + |
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cAMP inducers
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Enterotoxigenic E.Coli -
Vibrio cholerae - Bacillus anthracis + Bordetella pertussis - |
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Cytolysins
(lyse cells from outside by damging membranes) |
Clostridium perfringens +
Staphylococcus + |
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Corynebacterium diphtheriae
(+) |
Diphtheria toxin
MOA: ADP ribosyl transferase, inactivates eEF-2 -primary targets: heart, nerves, epithelium Role in Dz: inhibits eukaryotic cell protein synthesis |
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Pseudomonas aeruginosa
(-) |
Exotoxin A
MOA: ADP ribosyl transferase, inactivates eEF-2 -primary target: liver Role in Dz: inhibits eukaryotic cell protein synthesis |
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Shigella dysenteriae
(-) |
Shiga Toxin
MOA: interferes with 60S ribosomal subunit Role in Dz: inhibits eukaryotic cell protein synthesis -enterotoxic, cytotoxic and neurotoxic |
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Enterohemorrhagic E.coli
(EHEC) (-) |
Verotoxin (shiga like)
MOA: interferes with 60S ribosomal subunit Role in Dz: inhibits eukaryotic cell protein synthesis |
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Clostridium tetani
(+) |
Tetanus toxin
MOA: blocks release of inhibitor transmitters glycine and GABA Role in Dz: inhibits neurotransmission in inhibitory synapse |
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Clostridium botulinum
(+) |
Botulinum toxin
MOA: blocks release of ACh Role in Dz: inhibits cholingeric synapse |
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Staph Aureus
(superantigen) (+) |
Toxin: TSST-1
MOA: superantigen, pyrogenic, decrease liver clearance of LPS Role in Dz: fever, increased suspectibility to LPS, rash, shock, capillary leakage |
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Strep pyogenes
(+) |
Exotoxin A
MOA: similar to TSST-1 -superantigen Role in Dz: fever, increased suspectibility to LPS, rash, shock, capillary leakage, cardiotoxicity |
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Enterotoxigenic E.coli
(-) |
Heat labile toxin (LT)
MOA: LT stimulates an adenylate cyclase by ADP ribosylation of GTP binding protein Role in Dz: Both LT and ST promote secretion of fluid and electrolytes from intestinal epithelium |
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Vibrio cholerae
(-) |
Cholera toxin
MOA: similar to E.coli LT Role in Dz: profuse water diarrhea |
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Bacillus anthracis
(+) |
Anthrax toxin (3 proteins make 2 toxins)
MOA: edema factor --> adenylate cyclase lethal factor protective antigen Role in Dz: decreases phagocytosis, causes edema, kills cells |
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Bordetella pertussis
(-) |
Pertussis Toxin
MOA: ADP ribosylates Gi --> increase cAMP Role in Dz: histamine sensitizing, lymphocytosis promoting Islet activation |
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Clostridium perfringens
(+) |
Alpha Toxin
MOA: lecithinase Role in Dz: damage cell membranes, myonecrosis |
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Staph aureus
(cytolysin) (+) |
Alpha toxin
MOA: toxin intercalates forming pores Role in dz: cell membrane becomes leaky |
