Magnesium Sulfate

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Magnesium Sulfate

Classification
&
Special Considerations

Back 1

Classification:
 Electrolyte, tocolytic, mineral

Special Considerations:
 Pregnancy class A

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Magnesium Sulfate

Action

Back 2

Action:

 Cofactor in neuromuscular transmission and muscular excitability.
 Blocks peripheral neuromuscular transmission to control seizures.
 Peripheral vasodilator

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Magnesium Sulfate

Indications

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Indications:

 Torsades de pointes
 Eclampsia
 Status asthmaticus

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Magnesium Sulfate

Adverse Effects

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Effects:

 Magnesium toxicity
 Hypotension
 Muscle paralysis

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Magnesium Sulfate

Contraindications

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Contraindications:

 AV block
 GI obstruction
 Renal impairment

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Magnesium Sulfate

Dosage

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Dosage:

Ventricular Fib/Pulseless V-Tac w/ Torsades de Pointe:
 Adult: 1 to 2 g in 10 ml d5w,IV,IO over 5 min
 Pediatric: 25 to 50 mg/kg IV/IO over 10-20 min
Torsades de Pointe w/pulse or cardiac arrhythmias :
 Adult: 1 to 2 g in 50 to 100 ml d5w,IV,IO over 5-60 min
 Pediatric: 25 to 50 mg/kg IV, IO over 10 to 20 min
Eclampsia and Seizure prophylaxis in pre-eclampsia:
 Adult: 4 to 6 g IV/IO over 20-30 min
Status Asthmaticus:
 Adult: 1.2 to 2 g slow IV/IO over 20 min
 Pediatric: 25 to 50 mg/kg diluted in d5w over 20 min