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15 Cards in this Set
- Front
- Back
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Name the macrolide antibiotics
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Erythromycin
Clarithromycin (Biaxin) Azithromycin (Zithromax) Dirythromycin (Dynabac) ECAD Ketek |
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How do the macrolides work ?
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they bind to the 50s ribosomal subunit and block addition of new amino acids
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Are they bacteriostatic or cidal ?
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They are static at low doses and cidal at high doses
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What is the spectrum of use for these drugs ?
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Similar to penicillin, all gram +, some gram -
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Macrolides are the drug of choice for which diseases and conditions ?
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Pnuemonia caused by Legionaires disease or chlamydia
Pertussis (whooping cough) Diptheria Campylobacter |
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What gram negative organisms do macrolides cover ?
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H. flu
M.catarrhalis H pylori Mycobacterium |
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Instructions for use with the macrolides includes taking on an empty stomach with a full glass of water..TRUE OR FALSE?
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TRUE...food decreases the absorption of erythromycin
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Which macrolide is NOT a CP450 inhibitor ?
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Azithromycin (Zithromax)
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What is the expected reaction if your patient is on a macrolide and theophylline, coumadin or carbamezapine ?
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It will INHIBIT the metabolism of those drugs and therefore INCREASE the levels or toxicity of those drugs.
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Which macrolide could you give to a pregnant female ?
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Zithromax is a Category B.
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Which one is good for use in children < 6 months ?
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Zithromax is available in suspension
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Which drug is absolutely not for anyone < 18 ?
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Ketek
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Are the macrolides distributed to the CSF ?
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no
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How are they eliminated ?
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Primary hepatic elimination...avoid using in those with preexisting liver disease
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What are the signs and symptoms of liver toxicity ?
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darkened urine, yellow skin, pale stools, abdominal pain
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