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15 Cards in this Set

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Name the macrolide antibiotics
Erythromycin
Clarithromycin (Biaxin)
Azithromycin (Zithromax)
Dirythromycin (Dynabac)

ECAD
Ketek
How do the macrolides work ?
they bind to the 50s ribosomal subunit and block addition of new amino acids
Are they bacteriostatic or cidal ?
They are static at low doses and cidal at high doses
What is the spectrum of use for these drugs ?
Similar to penicillin, all gram +, some gram -
Macrolides are the drug of choice for which diseases and conditions ?
Pnuemonia caused by Legionaires disease or chlamydia

Pertussis (whooping cough)
Diptheria
Campylobacter
What gram negative organisms do macrolides cover ?
H. flu
M.catarrhalis
H pylori
Mycobacterium
Instructions for use with the macrolides includes taking on an empty stomach with a full glass of water..TRUE OR FALSE?
TRUE...food decreases the absorption of erythromycin
Which macrolide is NOT a CP450 inhibitor ?
Azithromycin (Zithromax)
What is the expected reaction if your patient is on a macrolide and theophylline, coumadin or carbamezapine ?
It will INHIBIT the metabolism of those drugs and therefore INCREASE the levels or toxicity of those drugs.
Which macrolide could you give to a pregnant female ?
Zithromax is a Category B.
Which one is good for use in children < 6 months ?
Zithromax is available in suspension
Which drug is absolutely not for anyone < 18 ?
Ketek
Are the macrolides distributed to the CSF ?
no
How are they eliminated ?
Primary hepatic elimination...avoid using in those with preexisting liver disease
What are the signs and symptoms of liver toxicity ?
darkened urine, yellow skin, pale stools, abdominal pain