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19 Cards in this Set

  • Front
  • Back
First major site of hematopoiesis
The yolk sac. stays there for about 6 weeks in humans.
Most blood cells produced in the yolk sac are red blood cells and retain their nuclei, in contrast to normal adult development.
Formation of blood components is initially intravascular
Second major site of hematop
At 6 weeks, yolk sac blood islands begin to regress, and the major site shifts to the fetal liver.
Throughout the midportion of pregnancy, the liver is the major hematopoietic organ.
The red cells released into circulation from the liver are normally without nuclei and presence of nucleated red blood cells in the fetal circulation indicates fetal hypoxia.
The final anatomical site of hematop during ontogeny
Medullary cavity of bone in humans. Human hematop cells can be seen there in 8-9 weeks, but this site becomes the major site at 5 months of gestation.
By the final trimester, all available medullary space is filled with hematop cells.
Bone marrow first appears in the
Bone marrow supersedes liver as the major hematop organ at 32-36 weeks of gestation
In Bone Marrow: % of Myeloblasts total, Type I and Type II Myeloblasts
Myeloblasts total = 3%
Type I = 1%
Type 2 = 2%
In Bone Marrow: % of Neutrophils total, promyelocytes, myelocytes, metamyelocytes, band forms, segmented neutrophils
Neutrophil total = 63%
-promyelocytes = 4%
-myelocytes = 13%
-metamyelocytes = 15%
-band forms = 16%
-segmented neutrophils = 15%
In Bone Marrow: % of Eosinophils
In Bone Marrow: % of Basophils
In Bone Marrow: % of Monocytes
In Bone Marrow: % of Normoblasts (Erythroblast) total, promonoblasts, basophilic normoblasts, polychromatophilic normoblasts, orthochromic normoblasts
Normoblasts total = 18.5%
-promonoblasts = 0.5%
-basophilic normoblast = 2%
-polychromatophilic normoblast = 12%
-orthochromic normoblast = 4%
In Bone Marrow: % of lymphocytes
In Bone Marrow: % of Megakaryocytes
less than 1%
Precursors of Basophil (3)
Myeloid Progenitor --> Myeloblast --> Immature Basophil --> Basophil
Precursors of Eosinophil (3)
Myeloid Progenitor --> Myeloblast --> Immature Eosinophil --> Eosinophil
Precursors of Neutrophil (6)
Myeloid Progenitor --> Myeloblast --> Normal Promyelocyte --> Normal Myelocyte --> Normal Metamyelocyte --> Normal Band --> Neutrophil
Precursors of Monocyte (2)
Myeloid Progenitor --> Immature Monocyte --> Monocyte
Precursors of Platelets (2)
Myeloid Progenitor --> Megakaryocyte --> Platelets
Precursors of Erythrocyte (6)
Myeloid Progenitor --> Pronormoblast --> Basophilic Normoblast --> Polychromatic Normoblast --> Orthochromatic Normoblast --> Polychormatic Erythrocyte --> Erythrocyte
Precursor of Lymphocyte (1)
Lymphoid Progenitor --> Lymphocyte