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9 Cards in this Set
- Front
- Back
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What is the importance of Lipoteichoic acid (LTA) and protein F in GAS infection?
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Binds fibronectin to facilitate adhesion
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What is the Importance of M protein GAS infection?
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Provide Scaffolding for LTA.
Binds keratinocyte to facilitate adhesion |
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What do streptolysin S and streptolysin O do?
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Hemolysins to aid in nutrient acquirement.
Streptolysin O is sensitive to oxygen Streptolysin S is oxygen stable |
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How does GAS escape complement?
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C5a peptidase
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What do Streptococcal Pyrogenic Exotoxins cause?
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SPE are superantigens
Responsible for Streptococcal Toxic Shock Syndrome and necrotizing fascitis Also causes Scarlet Fever |
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What is the importance of Streptokinase?
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Activates plasminogen to dissolve fibrin clots.
Allows strep to move through the body by removing local blood clots |
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What is the importance of Streptokinase?
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Activates plasminogen to dissolve fibrin clots.
Allows strep to move through the body by removing local blood clots |
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What is the importance of Hyrulonic Acid in GAS capsule?
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Antiphagocytic
Hyrulonic Acid is a major component of connective tissue and prevents immune response |
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What is Acute rheumatic fever (ARF)?
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Complication of pharyngitis
M protein (in some strains) is antigenically similar to myosin in heart valves Enhanced T cell response in heart valves to Streptococcal antigen --> Lifelong susceptability to bacterial endocarditis |
