Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
Most common viral-assoc'd cancers in men & women
|
Men = liver, women = cervical
|
|
|
What cell type is infected by HPV? How is the virus spread?
|
basal keratinocytes, viruses assemble as basal cells move to surface, spread through shedding s. corneum
|
|
|
Benign result of HPV infection and 2 outcomes
|
warts form that are either resolved, or cause cell transformation (viral genome integrated)
|
|
|
In terms of viral life cycle, what is the result of HPV integration into host genome
|
viral proteins are made, but no further virions are produced
|
|
|
Describe effects of HPV proteins E6 & E7
|
E6 binds p53, E7 binds Rb
|
|
|
2 HPV types commonly found in condyloma acuminatum
|
6, 11
|
|
|
2 HPV types commonly found in CIN/cervical cancer
|
16, 18
|
