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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Classic triad of Rickettsiae infection
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fever, headache, rash (replicate in endothelium = vasculitis)
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What class of organism are Rickettsiae?
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obligate intracell bacteria
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List 3 host factors that Rickettsiae take advantage of during infection
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CoA, ATP, NAD+
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Three things Coxiella more dangerous than other Rickettsiae?
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1. respiratory transmission (instead of through arthropods),
2. resist lysosomal degradation, 3. long term viability outside the cell (resist drying) |
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Two intracellular locations Rickettsiae can replicate
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1. w/in phagosome,
2. in cytoplasm (use phospholipase A to exit phagosome) |
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3 ways Rickettsiae can spread w/in a host
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1. via neighboring cells,
2. budd off, 3. lyse cell |
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Typical vector & reservoir of Rickettsiae
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Vector = insects (ticks, fleas, mites, lice);
Reservoir = rodents |
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Typical tx of Rickettsia infection
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tetracyclines
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Cause, vector, reservoir of Rocky Mountain Spotted Fever
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Cause = Rickettsia rickettsii,
Vector = wood & dog tick, Reservoir = dogs, sm rodents |
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Presentation of Rocky Mountain Spotted Fever
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1. fever,
2. severe headache, 3. rash initially involving extremities |
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Where is the highest distribution of Rocky Mountain Spotted Fever in the US?
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SE Atlantic, S central states
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Cause & vector of Rickettsialpox
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Rickettsia akari from bloodsucking mites
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3 phases of Rickettsialpox infection
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1. firm red papule/vesicle at bite site that turns black,
2. classic triad sxs, 3. self-limiting course (non-lethal) |
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Cause, vector & reservoir of Epidemic typhus
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Rickettsia prowazekii from body louse (in feces), human reservoir
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Contrast the rash found in RMSF & Epidemic Typhus*
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RMSF = starts on extremities,
ET = starts on trunk |
RMSF on wRists, Typhus on Trunk
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What is Brill-Zinsser dz
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milder relapse of Epidemic typhus
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What is the spread of Epidemic typhus assoc'd w/?
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unsanitary conditions and crowding
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Cause, vector & reservoir of Endemic (Murine) typhus
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Rickettsia typhi, rat/cat flea vector, rodent reservoir
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Typical location of Endemic Typhus in US
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temperate/subtropical coastal areas
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2 forms of Ehrlichiosis
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1. human monocyte ehrlichiosis (HME),
2. granulocytic ehrlichiosis (GE) |
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For both forms of Ehrlichiosis, common presentation & lab findings
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present w/ flu like illness, show leuko/thrombocytopenia & elevated transaminases
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