M2010.04.09- Renal Mech For Htn

Front 1

Contrast regulation of blood pressure:
1. short term
2. long term

Back 1

1. symNS effects on CO & TPR

2. renal effects on Na/H2O excretion

Front 2

Components that defind salt sensitive HTN

Back 2

10 mm or greater rise in MAP:
--measured after 4hrs of 2L NL saline
--compared to MAP after 1 day low Na diet & furosemide dosing

Front 3

2 categories of secondary HTN

Back 3

1. primarily volume mediated: renal vs nonrenal

2. primarily vasoconstrictor mediated

Front 4

Define renovascular HTN

Back 4

HTN resulting from stenosis of U/L or B/L renal a

Front 5

Results of U/L renal a stenosis w/ fxnal contralat kidney (3)

Back 5

1. increased BP

2. no change blood vol (pressure natriuresis in other kidney)

3. increased plasma renin (responds to ACEIs/ARBs)

Front 6

Contrast findings in B/L renal a stenosis to U/L

Back 6

--increased BP
--increased blood vol
--NO INCREASE in plasma renin

**Need ACEI/ARB + diuretic to correct

Front 7

Results of U/L renal a stenosis in a renal transplant pt

Back 7

increase BP
increase blood vol
*no change plasma renin (no response to ACEI/ARB)

Front 8

1. In general, how does chronic kidney dz lead to HTN?

Back 8

1. decreased GFR limits kidney's ability to excrete Na & H2O

Front 9

3 effects of essential HTN on the kidney

Back 9

1. afferent arteriolar hyalin arteriolosclerosis

2. progressive reduction in size

3. cortical atrophy & diffuse fibrosis

Front 10

Effect of malignant HTN on the kidney

Back 10

fibrinoid necrosis of arterioles

Front 11

Describe role of autoregulation in the kidney

Back 11

impedes transmission of changes in systemic arterial pressure to glomeruli/peritubular capillaries

--prevents damage to capillaries