M2010.04.06- Herpes

Front 1

Herpes Simplex 1:
1. common primary infections (4)
2. Where does latent infection reside?
3. Site of recurrent infection
4. sxs of recurrent infection compared to primary

Back 1

1. cold sores (herpes labialis), sore throat, fever, encephalitis

2. Trigeminal ganglion

3. epithelium around nose/mouth

4. milder 2nd time around

Front 2

Herpes simplex 2:
1. Primary infection - what, how, who?
2. Where does latent infection reside?
3. Location of recurrent infection

Back 2

1. genital vesicular eruptions, spread sexually to both sexes

2. sacral ganglion

3. mild outbreak in same area as primary

Front 3

Acyclovir:
1. What is it?
2. MOA
3. tx for what 3 viruses?
4. 2 MORs

Back 3

1. Guanosine analog after phos'd by viral thymidine kinase

2. causes chain termination in viral DNA polymerase

3. HSV, VZV, EBV

4. lack thymidine kinase, different DNA polymerase

Front 4

Foscarnet:
1. MOA
2. tx for what 2 viruses?

Back 4

1. pyrophosphate analog that inhibs viral DNA polymerase

2. CMV, acyclovir-resistant HSV

Front 5

Varicella zoster virus:
1. Transmission
2. Primary infection
3. 3 complications

Back 5

1. respiratory

2. generalized pruitic vesicular rash following 1-2 wk prodrome

3. bacterial infection of lesions, CNS manifestations, pneumonia

Front 6

VZV vaccine:
1. type
2. usually administered w/ what other vaccine?

Back 6

1. live atten'd

2. MMR

Front 7

VZV:
1. location of latent infection
2. location of recurrent infection
3. Possible mechanism to reduce recurrent infection

Back 7

1. DRG

2. epithelium innervated by fibers from infected DRG (shingles)

3. vaccination

Front 8

EBV:
1. causes what primary infection?
2. What is infected?
3. 4 s&sxs
4. peak age incidence
5. Transmission

Back 8

1. mononucleosis

2. B cells causing growth

3. fever, HSM, LAD, pharyngitis

4. 15-20 yo

5. saliva

Front 9

2 means of detecting EBV infection

Back 9

1. Monospot test - detect heterophile Abs

2. Ab to viral capsule Ag (IgG/M)

Front 10

5 clinical syndromes of EBV infection

Back 10

1. infectious mononucleosis

2. post-transplant lymphoproliferative ds

3. Hairy oral leukoplakia (w/ AIDS)

4. Afr. Burkitt's Lymphoma (w/ malaria)

5. nasopharyngeal carcinoma

Front 11

Cytomegalovirus:
1. transmission
2. 2 groups w/ highest risk of symptomatic & recurrent dz
3. How does recurrent infection occur?

Back 11

1. congenital, any fluids (blood, semen, milk, urine, saliva)

2. babies, IC'd pts

3. suppressed CMI

Front 12

CMV:
1. 3 common syndromes
2. Characteristic histo finding

Back 12

1. mononucleosis (Monospot neg), pneumonia, congenital infection

2. owl's eyes appearance of infected cells

Front 13

Ganciclovir:
1. What is it?
2. MOA
3. tx use
4. 2 problems w/ use

Back 13

1. Guanosine analog formed by kinase in CMV, HSV, or VZV

2. inhibits viral DNA polymerase through chain termination

3. renal toxicity, pancytopenia

Front 14

HHV 6 & 7:
1. another name
2. path of primary infection
3. how is infection resolved?

Back 14

1. roseola

2. rapid onset of high fever, generalized rash 1-2 days later

3. T cell resolution & latency

Front 15

1. Most common neoplasm in AIDS pts
2. Caused by what virus?
3. Transmission

Back 15

1. Kaposi's Sarcoma

2. HHV-8

3. sexual