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6 Cards in this Set
- Front
- Back
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General rule for % fat in healthy bone marrow
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% = age
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1. What are symptoms of polycythemia vera related to?
2. Mutation found 3. Finding that distinguishes PCV from other polycythemias 4. Phenomena that often occur in PCV 5. Lab & physical findings |
1. increase RBC mass
2. Jak2 3. extremely low EPO 4. thrombotic & hemorrhagic from sludging 5. increased Hct, WBCs, & platelets; splenomegaly |
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Chronic myelogenous leukemia:
1. genetic mutation 2. appearance of bone marrow 3. distinguish from leukemoid rxn 4. what causes initial conditions? |
1. philadelphia chromosome [t(9;22)] creating Bcr-abl gene w/ tyr kinase activity
2. 100% cellular, mainly w/ granulocytes but some MKCs 3. Has Ph chrom, splenomegaly, and N0s in all stages of maturation 4. anemia |
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Chronic idiopathic myelofibrosis:
1. early vs late bone marrow appearance 2. changes to spleen and liver 3. 2 findings in peripheral blood smear |
1. early: hypercellular w/ trilineage prolif
late: fibrotic marrow 2. enlarge b/c of extramed hematopoiesis 3. nRBCs and tear drop cells |
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Essential thrombocythemia:
1. What cell lineage is predominantly prolif'ing? 2. genetic mutation (2 parts) 3. Type of abNLs and result clinically |
1. MKC lineage
2. Jak2 or excluded other MPDs if Jak2 mutation isn't present 3. quant and qual abNLs of platelets (throm/hemorr) |
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1. What are myelodysplastic dss?
2. 2 etiologies 3. 4 types |
1. NL marrow replaced by neoplastic multipotent SCs, can create 3 lineages, but ineffectively
2. idiopathic, toxic exposure 3. disordered, erythroid, myeloid, MKC |
