M2-C3-L84 --> Picornovirus I

Front 1

Which picornovirus genera is associated with the common cold?

Back 1

Rhinovirus

Front 2

For rhinoviruses, what is th optimal temperature for replication?

Why is this important?

Back 2

33 degree (Patrick Ewing is a rhino)

Means they can't replicate in most places of the body where it is warm.

Can replicate in the URT where cooler.

Front 3

Is there likely going to be a vaccine for rhinovirus?

why or why not?

Back 3

NO

b/c over 100 serotypes

Front 4

Enterovirus:

- replicate where?
- what ability makes that possible?

Back 4

GI

Stable at acid pH

(can also grow warmer 37C places)

Front 5

If unimpeded, enteroviruses can go where from the GI?

Then can go where?

Back 5

Bloodstream (VIREMIA)

Central Nervous System (CNS)

Front 6

Infection with the enterovirus will most like give you what symptoms usually?

Back 6

Asymptomatic

Front 7

List three enteroviruses.

Back 7

Poliovirus, echovirus, Coxsackie virus

Front 8

Enterovirus:

- Primary transmission
- Secondary transmission?

Back 8

Fecal-oral

Inhalation of respiratory droplets

Front 9

During the summer and fall seasons, most infections of enterovirus occurs with what population group?

Back 9

Children

Front 10

T/F - For enterovirus, a specific syndrome can by uniquely associated with one specific virus.

Back 10

FALSE

Lots of overlap in clinical syndromes.

Front 11

Poliomyelitis:

- # of serotypes
- # of phases
- % of polio pts that develop paralytic poliomyelitis.
- Paralytic poliomyelitis occurs mostly in what population group?

Back 11

3 serotypes
2 phases (biphasic)
1% develop paralytic poliomyelitis

Adults mostly

Front 12

What is abortive polio?

Back 12

When polio symptoms stop at the first phase of symptoms, and does NOT progress.

Front 13

In the second phase of polio, what is the mechanism?

Clinical condition?

Back 13

Viremia causes spread to CNS

Aseptic meningitis

Front 14

Paralytic Poliomyelitis

- what percent of polio pts?
- mostly what population group?
- clinical symptom
- pathogenesis

Back 14

1 percent

Mostly adults

Flaccid paralysis

Destruction of motor neurons in the anterior horn of Cervical or Lumbar spinal cord.

Front 15

What is spinal poliomyelitis?

Back 15

Destruction motor neurons of the anterior horn of spinal cord (C or L)

Front 16

Bulbar paralysis:

- associated with what enterovirus disease
- pathogenesis
- symptoms
- fatality?

Back 16

Poliomyelitis

Damage to neurons in the brainstem

Inability to smallow and breathe

Often fatal

Front 17

Encephalitis

- associated with what enterovirus disease?
- pathogenesis

Back 17

poliomyelitis

replication in the motor cortex

Front 18

In post polio syndrome,

what virus is responsible?

Back 18

No virus present

Front 19

In Enterovirus associated aseptic meningitis, what is the most prevalent population group?

Back 19

Children

Front 20

Pleurodynia:

- aka x3
- symptoms x2

Back 20

Bornholm dz
Epidemic myalgia
Devil's grip

Intense CP
Intense upper abd pain

Front 21

Herpangina:

- which herpes virus
- classic sign

Back 21

NONE. This is still enterovirus

Gray Papulovesicular lesions to fauces, throat, tongue, tonsils

Front 22

Hand-foot-mouth disease:

- symptoms x2
- specific virus associated
- possibly enter internal system?

Back 22

Enanthem
(red ulcerative lesions to mouth)

Exanthem
(vesicular lesions to hand and foot)

Enterovirus 71

Can enter CNS
(past epidemics had fatality with Encephalitis and Myocarditis)

Front 23

Enterovirus eye disease

- virus responsible
- major symptom

Back 23

Enterovirus 70

Acute Hemorrhagic Conjunctivitis

Front 24

Enterovirus Cardiac disease

- name two diseases
- mechanism responsible

Back 24

Acute Myocarditis
Dilated Cardiomyopathy

AUTOIMMUNE response

Front 25

Diagnosis method in lab testing for enterovirus.

Limitation?

Back 25

RT-PCR assay

Can tell you enterovirus, but not which one

Front 26

Three eras of the poliomyelitis epidemiology

Back 26

Endemic

Epidemic

Vaccine Era

Front 27

IPV:

- administered how
- contains
- discoverer

Back 27

IV

Inactive (Killed) virus of all THREE serotypes

SalK

Front 28

OPV:

- administered how
- contains
- discoverer

Back 28

OrAL

Live Attenuated virus of all three serotypes

sAbin

Front 29

OPV benefits x2

Back 29

B/c alive, can replicate in GI, forcing a IgA response immunity:

Thus,

- Mucosal immunity in GI
- Temporary excretion with vaccine-virus can infect-immunize a close contact

Front 30

OPV drawback x1

Back 30

Serotype 3 has the tendency to revert to NEUROVIRULENT, causing VAPP (Vaccine Associated Paralytic Poliomyelitis)