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30 Cards in this Set

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Which picornovirus genera is associated with the common cold?
Rhinovirus
For rhinoviruses, what is th optimal temperature for replication?

Why is this important?
33 degree (Patrick Ewing is a rhino)

Means they can't replicate in most places of the body where it is warm.

Can replicate in the URT where cooler.
Is there likely going to be a vaccine for rhinovirus?

why or why not?
NO

b/c over 100 serotypes
Enterovirus:

- replicate where?
- what ability makes that possible?
GI

Stable at acid pH

(can also grow warmer 37C places)
If unimpeded, enteroviruses can go where from the GI?

Then can go where?
Bloodstream (VIREMIA)

Central Nervous System (CNS)
Infection with the enterovirus will most like give you what symptoms usually?
Asymptomatic
List three enteroviruses.
Poliovirus, echovirus, Coxsackie virus
Enterovirus:

- Primary transmission
- Secondary transmission?
Fecal-oral

Inhalation of respiratory droplets
During the summer and fall seasons, most infections of enterovirus occurs with what population group?
Children
T/F - For enterovirus, a specific syndrome can by uniquely associated with one specific virus.
FALSE

Lots of overlap in clinical syndromes.
Poliomyelitis:

- # of serotypes
- # of phases
- % of polio pts that develop paralytic poliomyelitis.
- Paralytic poliomyelitis occurs mostly in what population group?
3 serotypes
2 phases (biphasic)
1% develop paralytic poliomyelitis

Adults mostly
What is abortive polio?
When polio symptoms stop at the first phase of symptoms, and does NOT progress.
In the second phase of polio, what is the mechanism?

Clinical condition?
Viremia causes spread to CNS

Aseptic meningitis
Paralytic Poliomyelitis

- what percent of polio pts?
- mostly what population group?
- clinical symptom
- pathogenesis
1 percent

Mostly adults

Flaccid paralysis

Destruction of motor neurons in the anterior horn of Cervical or Lumbar spinal cord.
What is spinal poliomyelitis?
Destruction motor neurons of the anterior horn of spinal cord (C or L)
Bulbar paralysis:

- associated with what enterovirus disease
- pathogenesis
- symptoms
- fatality?
Poliomyelitis

Damage to neurons in the brainstem

Inability to smallow and breathe

Often fatal
Encephalitis

- associated with what enterovirus disease?
- pathogenesis
poliomyelitis

replication in the motor cortex
In post polio syndrome,

what virus is responsible?
No virus present
In Enterovirus associated aseptic meningitis, what is the most prevalent population group?
Children
Pleurodynia:

- aka x3
- symptoms x2
Bornholm dz
Epidemic myalgia
Devil's grip

Intense CP
Intense upper abd pain
Herpangina:

- which herpes virus
- classic sign
NONE. This is still enterovirus

Gray Papulovesicular lesions to fauces, throat, tongue, tonsils
Hand-foot-mouth disease:

- symptoms x2
- specific virus associated
- possibly enter internal system?
Enanthem
(red ulcerative lesions to mouth)

Exanthem
(vesicular lesions to hand and foot)

Enterovirus 71

Can enter CNS
(past epidemics had fatality with Encephalitis and Myocarditis)
Enterovirus eye disease

- virus responsible
- major symptom
Enterovirus 70

Acute Hemorrhagic Conjunctivitis
Enterovirus Cardiac disease

- name two diseases
- mechanism responsible
Acute Myocarditis
Dilated Cardiomyopathy

AUTOIMMUNE response
Diagnosis method in lab testing for enterovirus.

Limitation?
RT-PCR assay

Can tell you enterovirus, but not which one
Three eras of the poliomyelitis epidemiology
Endemic

Epidemic

Vaccine Era
IPV:

- administered how
- contains
- discoverer
IV

Inactive (Killed) virus of all THREE serotypes

SalK
OPV:

- administered how
- contains
- discoverer
OrAL

Live Attenuated virus of all three serotypes

sAbin
OPV benefits x2
B/c alive, can replicate in GI, forcing a IgA response immunity:

Thus,

- Mucosal immunity in GI
- Temporary excretion with vaccine-virus can infect-immunize a close contact
OPV drawback x1
Serotype 3 has the tendency to revert to NEUROVIRULENT, causing VAPP (Vaccine Associated Paralytic Poliomyelitis)