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36 Cards in this Set
- Front
- Back
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List the three definite criteria for helical capsid. X3
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1X RNA
Enveloped always Only 1 species of viral proteins (proteosomes) |
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Define pitch
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Distance between two helical turns
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In helical capsids, what is the maximum amount of 1X RNA per capsule?
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1 per capsule
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List the helical capsid viridae families that have multiple molecules. List the # of molecules for which. x3
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Adenoviridae - 2
Bunyaviridae - 3 Orthomyxoviridae - 8 |
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Influenza A is caused by what virus family?
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Orthomyxoviridae
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Measles is caused by what virus family?
What capsid? |
Paramyxoviridae
Helical |
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Rabies is caused by what virus family?
What capsid |
Rhabdoviridae
Helical |
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Filiviridae viruses x3
What type of capsid? |
Filovirus
Ebola virus Marburg virus All are helical capsids |
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Which helical capsid virus family does not have M proteins?
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Bunyaviridae
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Icosahedral capsid:
- Axes of symmetry x3 - Faces - Edges - Vertices |
2 fold, 3 fold, 5 fold
20 30 12 |
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For icosahedral viruses, if the faces are subdivided into additional triangles by the T number, what is this called?
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Icosadeltahedral
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What is a unique structure associated with the herpesviridae family?
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Has a tegument
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List the two viruses associated with Picornoviridae.
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Poliovirus
Coxsackie virus |
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Describe the structural differences between poliovirus and coxsackie virus.
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Poliovirus
(5 trimers of VP1, VP2, VP3) Coxsackie virus (Pentamers of VP2) (Hexamers of VP1 and VP3) |
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Rotovirus is associated with which virus family?
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Reoviridae
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Norovirus (Norwalk agent) is associated with which virus family?
Diseases associated with this? x2 |
Calciviridae
Gastroenteritis Hepatitis E |
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What is the unique structure associated with adenoviruses?
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Fibers at each vertex
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What is the best example of a virus family with a complex symmetry capsid?
List one more virus family |
Poxviridae
Retroviridae |
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Envelope:
- structure - derived from what? |
Lipid bilayer
Cellular membrane |
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What is unique about the envelope seen in herpes?
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Derived from nucleus.
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Peplomer:
- define - encoded by - glycosylated by - where |
Transmembrane glycoprotein
Viral encoded Cellular enzymes ER and Golgi |
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List the two types of linked oligosaccharides of peplomer proteins.
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N - linked oligosaccharides
O - linked oligosaccharides |
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N-linked oligosaccharides:
- what gets added to where? |
Mannose rich oligosaccharides added to ASP-X-SER.
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O-linked oligosaccharides:
- what gets added to where? |
Galactamine & Glucosamine added to
SER or THR |
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List the two unique peplomers of Influenzavirus type A
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HA
NA |
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HA Peplomer
- structure - function - what needs to happen for activation and what does this? |
trimer
mediates attachment and invasion (fusion) Must be cleaved by cellular protease |
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NA Peplomer:
- structure - function |
Tetramer
Digests mucus in URT to allow virus to reach epithelium |
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Only ______ viruses fuse at plasma membrane.
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Enveloped
b/c they have peplomers |
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What are the attachment and fusion peplomers of paramyxoviridae?
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H
F |
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What are the attachment and fusion peplomers of herpesviridae?
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gB
gD |
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What is a specialized structure seen in arenaviridae?
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Trapped ribosomes
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What is a specialized structure seen in orthomyxoviridae type A.
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M2 Protein
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Describe M2 protein.
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Proton channel
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What is an effective treatment against the M2 protein?
How does it work |
Amantadine HCl
Binds and blocks channel |
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Tegument:
- what family of virus has it - located where on virus |
Herpesviridae
between envelope and capsid |
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T/F - Amantidine is effective in treatment of Influenza Type B.
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False, only effective against type A.
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