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36 Cards in this Set

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List the three definite criteria for helical capsid. X3
1X RNA

Enveloped always

Only 1 species of viral proteins
(proteosomes)
Define pitch
Distance between two helical turns
In helical capsids, what is the maximum amount of 1X RNA per capsule?
1 per capsule
List the helical capsid viridae families that have multiple molecules. List the # of molecules for which. x3
Adenoviridae - 2
Bunyaviridae - 3
Orthomyxoviridae - 8
Influenza A is caused by what virus family?
Orthomyxoviridae
Measles is caused by what virus family?

What capsid?
Paramyxoviridae

Helical
Rabies is caused by what virus family?

What capsid
Rhabdoviridae

Helical
Filiviridae viruses x3

What type of capsid?
Filovirus
Ebola virus
Marburg virus

All are helical capsids
Which helical capsid virus family does not have M proteins?
Bunyaviridae
Icosahedral capsid:

- Axes of symmetry x3
- Faces
- Edges
- Vertices
2 fold, 3 fold, 5 fold

20
30
12
For icosahedral viruses, if the faces are subdivided into additional triangles by the T number, what is this called?
Icosadeltahedral
What is a unique structure associated with the herpesviridae family?
Has a tegument
List the two viruses associated with Picornoviridae.
Poliovirus
Coxsackie virus
Describe the structural differences between poliovirus and coxsackie virus.
Poliovirus
(5 trimers of VP1, VP2, VP3)

Coxsackie virus
(Pentamers of VP2)
(Hexamers of VP1 and VP3)
Rotovirus is associated with which virus family?
Reoviridae
Norovirus (Norwalk agent) is associated with which virus family?

Diseases associated with this? x2
Calciviridae

Gastroenteritis
Hepatitis E
What is the unique structure associated with adenoviruses?
Fibers at each vertex
What is the best example of a virus family with a complex symmetry capsid?

List one more virus family
Poxviridae

Retroviridae
Envelope:

- structure
- derived from what?
Lipid bilayer

Cellular membrane
What is unique about the envelope seen in herpes?
Derived from nucleus.
Peplomer:

- define
- encoded by
- glycosylated by
- where
Transmembrane glycoprotein

Viral encoded

Cellular enzymes

ER and Golgi
List the two types of linked oligosaccharides of peplomer proteins.
N - linked oligosaccharides

O - linked oligosaccharides
N-linked oligosaccharides:

- what gets added to where?
Mannose rich oligosaccharides added to ASP-X-SER.
O-linked oligosaccharides:

- what gets added to where?
Galactamine & Glucosamine added to

SER or THR
List the two unique peplomers of Influenzavirus type A
HA
NA
HA Peplomer

- structure
- function
- what needs to happen for activation and what does this?
trimer

mediates attachment and invasion (fusion)

Must be cleaved by cellular protease
NA Peplomer:

- structure
- function
Tetramer

Digests mucus in URT to allow virus to reach epithelium
Only ______ viruses fuse at plasma membrane.
Enveloped

b/c they have peplomers
What are the attachment and fusion peplomers of paramyxoviridae?
H

F
What are the attachment and fusion peplomers of herpesviridae?
gB

gD
What is a specialized structure seen in arenaviridae?
Trapped ribosomes
What is a specialized structure seen in orthomyxoviridae type A.
M2 Protein
Describe M2 protein.
Proton channel
What is an effective treatment against the M2 protein?

How does it work
Amantadine HCl

Binds and blocks channel
Tegument:

- what family of virus has it
- located where on virus
Herpesviridae

between envelope and capsid
T/F - Amantidine is effective in treatment of Influenza Type B.
False, only effective against type A.