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7 Cards in this Set

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Pyrantel Pamoate

- used to treat what? x3
- mechanism
- affects on host
Ascaris infection
Pinworm infection
Hookworm infection

Inhibits cholinesterases
(Neuromuscular Blocker)
(thus paralyzing worm and passes thru fecal shit)

None, b/c poorly absorbed from host's intestine
What drugs have similar effects on intestinal worms as Pyrantel Pamoate, but uses different mechanism?

Name drug and mechanism
Piperazine
Diethylcarbamazine

GABA agonist
(causes paralysis thus pooped out with rest of the shit)
What drugs will essentially starve a parasite to death in the intestine? x3
Albendazole
Thiabendazole
Mebendazole
Albendazole
Thiabendazole
Mebendazole

Describe the mechanism which will starve a parasite to death.
Binds to cytoplasmic b-tubulin

Will inhibit POLYmerization of microtubules

Thus preventing uptake of nutrients by the parasite.
Praziquantel:

- treats for what?
- mechanism x2
Broad spectrum anti-helmenthic

1. Serves as Ca2+ agonist, thus increasing membrane permeability (and tetanic muscular contractions)

2. Causes vacuolization and disintegration of the schistosome tegument
Ivermectin

- treatment for what?
- mechanism
Filarial infections

Binding to Glutamate-gated chloride channels
(blocks neuromuscular action
in the muscle and nerve cells --> CELL DEATH)
Niclosamide:

- treats what?
- mechanism
- outcome
intestinal tapeworms

uncouples oxidative phosphorylation
- inhibits glucose uptake
- inhibits E production
- inhibits phosphate incorporation into ATP

Affects head and proximal segments of worm leading to detachment from the intestinal wall.