M2-C3-L48B --> Medical Parasitology Ii (Anti-Helminth Drugs)

Front 1

Pyrantel Pamoate

- used to treat what? x3
- mechanism
- affects on host

Back 1

Ascaris infection
Pinworm infection
Hookworm infection

Inhibits cholinesterases
(Neuromuscular Blocker)
(thus paralyzing worm and passes thru fecal shit)

None, b/c poorly absorbed from host's intestine

Front 2

What drugs have similar effects on intestinal worms as Pyrantel Pamoate, but uses different mechanism?

Name drug and mechanism

Back 2

Piperazine
Diethylcarbamazine

GABA agonist
(causes paralysis thus pooped out with rest of the shit)

Front 3

What drugs will essentially starve a parasite to death in the intestine? x3

Back 3

Albendazole
Thiabendazole
Mebendazole

Front 4

Albendazole
Thiabendazole
Mebendazole

Describe the mechanism which will starve a parasite to death.

Back 4

Binds to cytoplasmic b-tubulin

Will inhibit POLYmerization of microtubules

Thus preventing uptake of nutrients by the parasite.

Front 5

Praziquantel:

- treats for what?
- mechanism x2

Back 5

Broad spectrum anti-helmenthic

1. Serves as Ca2+ agonist, thus increasing membrane permeability (and tetanic muscular contractions)

2. Causes vacuolization and disintegration of the schistosome tegument

Front 6

Ivermectin

- treatment for what?
- mechanism

Back 6

Filarial infections

Binding to Glutamate-gated chloride channels
(blocks neuromuscular action
in the muscle and nerve cells --> CELL DEATH)

Front 7

Niclosamide:

- treats what?
- mechanism
- outcome

Back 7

intestinal tapeworms

uncouples oxidative phosphorylation
- inhibits glucose uptake
- inhibits E production
- inhibits phosphate incorporation into ATP

Affects head and proximal segments of worm leading to detachment from the intestinal wall.