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22 Cards in this Set

  • Front
  • Back
Give an example of a Beta Amyloidopathy.
Alzheimer's
Give examples of Tauopathy. x4
PSP
Corticobasal degeneration
Pick's Disease
FTDP-17
Give examples of Alpha Synucleinopathy. x3
Parkinson's
Multiple System Atrophy
Dementia with Lewy Bodies
Give examples of Triplet (CAG) repeat Disease. x2
Huntington's

Spinocerebellar atrophy
Give an example of prionopathy.
Creutfeld-Jacob
T/F - There is a lack of inflammation in system degeneration diseases.
False
Cortical system degeneration diseases. x5
Alzheimer's
Creutzfeld-Jacob
Dementia with Lewy Bodies
Corticobasal

FTDP
Basal Ganglia system degeneration diseases. x5
Huntingon's
Dementia with Lewy bodies
Parkinson's
Parkinson's Plus syndromes

FTDP-17
Spinal cord, cerebellum, brainstem degeneration diseases. x3
Friedreich's Ataxia
Multiple system atrophy
Inherited Spinocerebellar atrophy
System degeneration refers to the system of ________ involvement.
Predominant
All neurodegenerative diseases are characterized by nonspecific microscopic changes (neuronal loss and gliosis) involving ________ neuronal populations.
Selectively vulnerable
NFT's are predominantly composed of what?
Tau protein
T/F - The tau protein is the same in Alzheimers, PSP, Corticobasal degeneration, and Pick's disease.
False.

Alzheimer's tau is different, that is why it is in Beta amyloid category
TDP-43 protein is found in what diseases?
ALS
What is the precursor for beta amyloid, and how does beta amyloid accumulation occur?
APP (amyloid precursor protein)

Metabolism of APP via "alternate" pathway.
Lewy bodies and Lewy neurites are found in what diseases? x2
Parkinson's

Dementia with lewy body
Nuclear and cytoplasmic inclusions are found in what type of diseases?
Triplet (CAG) repeats

(HD and Spinocerebellar atrophy)
Creutzfeld-Jacob dementia has what type of unique microscopic feature? x2
Spongiform change

+

Plaques
NFT's and GVD's are found in what diseases? x2
Alzheimer's

PSP
Ballooned neurons are found where? x2
Corticobasal degeneration

Pick's
In alzheimer's, the greatest number of NFT's occurs where?

What about senile plaques?
Hippocampus

Neocortex and amygdala
What is the PATHOLOGICAL hallmark of Huntington's disease?
Atrophy of caudate and putamen.

(explains the hyperkinetic result)