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22 Cards in this Set
- Front
- Back
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Give an example of a Beta Amyloidopathy.
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Alzheimer's
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Give examples of Tauopathy. x4
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PSP
Corticobasal degeneration Pick's Disease FTDP-17 |
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Give examples of Alpha Synucleinopathy. x3
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Parkinson's
Multiple System Atrophy Dementia with Lewy Bodies |
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Give examples of Triplet (CAG) repeat Disease. x2
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Huntington's
Spinocerebellar atrophy |
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Give an example of prionopathy.
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Creutfeld-Jacob
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T/F - There is a lack of inflammation in system degeneration diseases.
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False
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Cortical system degeneration diseases. x5
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Alzheimer's
Creutzfeld-Jacob Dementia with Lewy Bodies Corticobasal FTDP |
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Basal Ganglia system degeneration diseases. x5
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Huntingon's
Dementia with Lewy bodies Parkinson's Parkinson's Plus syndromes FTDP-17 |
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Spinal cord, cerebellum, brainstem degeneration diseases. x3
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Friedreich's Ataxia
Multiple system atrophy Inherited Spinocerebellar atrophy |
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System degeneration refers to the system of ________ involvement.
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Predominant
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All neurodegenerative diseases are characterized by nonspecific microscopic changes (neuronal loss and gliosis) involving ________ neuronal populations.
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Selectively vulnerable
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NFT's are predominantly composed of what?
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Tau protein
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T/F - The tau protein is the same in Alzheimers, PSP, Corticobasal degeneration, and Pick's disease.
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False.
Alzheimer's tau is different, that is why it is in Beta amyloid category |
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TDP-43 protein is found in what diseases?
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ALS
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What is the precursor for beta amyloid, and how does beta amyloid accumulation occur?
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APP (amyloid precursor protein)
Metabolism of APP via "alternate" pathway. |
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Lewy bodies and Lewy neurites are found in what diseases? x2
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Parkinson's
Dementia with lewy body |
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Nuclear and cytoplasmic inclusions are found in what type of diseases?
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Triplet (CAG) repeats
(HD and Spinocerebellar atrophy) |
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Creutzfeld-Jacob dementia has what type of unique microscopic feature? x2
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Spongiform change
+ Plaques |
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NFT's and GVD's are found in what diseases? x2
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Alzheimer's
PSP |
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Ballooned neurons are found where? x2
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Corticobasal degeneration
Pick's |
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In alzheimer's, the greatest number of NFT's occurs where?
What about senile plaques? |
Hippocampus
Neocortex and amygdala |
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What is the PATHOLOGICAL hallmark of Huntington's disease?
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Atrophy of caudate and putamen.
(explains the hyperkinetic result) |
