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16 Cards in this Set
- Front
- Back
T/F - Schizophrenia is a deficiency of dopamine antagonists.
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False
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T/F - Schizophrenia and other psychiatric illnesses are syndromes.
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True
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T/F - Schizophrenia is not a diagnosis of exclusion
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False
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What are psychotic symptoms associated with schizophrenia? x5
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Hallucinations
Delusions Disorganized speech Disorganized/catatonic behavior Negative symptoms |
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What is the DSM-IV diagnosis of Schizophrenia? x5
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1. Psychotic symptoms (2 or more) for 1 month
2. Impairment of social or occupational functioning. 3. Duration of illness at least 6 months 4. Symptoms not due to mood disorder or schizoaffective 5. Symptoms not due to medical, neurological, or substance induced disorder. |
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What are the negative symptoms associated with schizophrenia. x5
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Affective flattening
Alogia Avolition Anhedonia Attention impairment |
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What are the positive symptoms associated with schizophrenia? x4
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Hallucination
Delusions Affective instability Behavioral dyscontrol |
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Anatomical abnormalities associated with schizophrenia. x4
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Smaller total brain
Enlarged Lateral ventricles Widened third ventricle Cortical atrophy |
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What does the PET and SPECT studies show regarding Schizophrenics?
- What's normal? - What fails in the brain? |
Normal cerebral flow/metabolism
Failure to activate dorsolateral prefrontal cortex |
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All typical antipsychotics do what?
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Block D2 receptors
with varying affinity |
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T/F - Dopamine antagonists can precipitate a psychosis.
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False
Dopamine AGONISTS do |
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List the three main dopamine systems in the body.
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Nigrostriatal
Mesolimbic Mesocortical |
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The dysfunction of mesolimbic dopamine system would lead to what clinical schizophrenic symptom? What happens with the dopamine levels?
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Positive symptoms
Dopamine levels are increased |
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The dysfunction of Mesocortical dopamine system would lead to what clinical schizophrenic symptom? What happens with dopamine levels?
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Negative symptoms
Depressed dopamine levels |
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List the neuroleptic side effects. x4
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Tardive dyskinesia
Akathisia Parkinsonian side effects Acute dystonia |
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How is atypical antipsychotics different from typical antipsychotics?
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Broader spectrum of receptor activity. (serotonin, dopamine, GABA)
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