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16 Cards in this Set

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T/F - Schizophrenia is a deficiency of dopamine antagonists.
False
T/F - Schizophrenia and other psychiatric illnesses are syndromes.
True
T/F - Schizophrenia is not a diagnosis of exclusion
False
What are psychotic symptoms associated with schizophrenia? x5
Hallucinations
Delusions
Disorganized speech
Disorganized/catatonic behavior
Negative symptoms
What is the DSM-IV diagnosis of Schizophrenia? x5
1. Psychotic symptoms (2 or more) for 1 month

2. Impairment of social or occupational functioning.

3. Duration of illness at least 6 months

4. Symptoms not due to mood disorder or schizoaffective

5. Symptoms not due to medical, neurological, or substance induced disorder.
What are the negative symptoms associated with schizophrenia. x5
Affective flattening
Alogia
Avolition
Anhedonia
Attention impairment
What are the positive symptoms associated with schizophrenia? x4
Hallucination
Delusions
Affective instability
Behavioral dyscontrol
Anatomical abnormalities associated with schizophrenia. x4
Smaller total brain
Enlarged Lateral ventricles
Widened third ventricle
Cortical atrophy
What does the PET and SPECT studies show regarding Schizophrenics?

- What's normal?
- What fails in the brain?
Normal cerebral flow/metabolism

Failure to activate dorsolateral prefrontal cortex
All typical antipsychotics do what?
Block D2 receptors

with varying affinity
T/F - Dopamine antagonists can precipitate a psychosis.
False

Dopamine AGONISTS do
List the three main dopamine systems in the body.
Nigrostriatal

Mesolimbic

Mesocortical
The dysfunction of mesolimbic dopamine system would lead to what clinical schizophrenic symptom? What happens with the dopamine levels?
Positive symptoms

Dopamine levels are increased
The dysfunction of Mesocortical dopamine system would lead to what clinical schizophrenic symptom? What happens with dopamine levels?
Negative symptoms

Depressed dopamine levels
List the neuroleptic side effects. x4
Tardive dyskinesia
Akathisia
Parkinsonian side effects
Acute dystonia
How is atypical antipsychotics different from typical antipsychotics?
Broader spectrum of receptor activity. (serotonin, dopamine, GABA)