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NoradrenaLine is one of the four monoamines; with cell bodies of the NA pathways in brain in pons & medulla where are the respective clusters

LC Locus coeruleus (pons)


LTC Lateral tegmentum (of brainstem reticular formation)

The reticular formation is the neuronal core of the brainstem & has 3 main "zones"

Lateral (predominantly sensory)


Medial (predominantly motor)


Raphe nuclei (serotonergic)

NA transmission is believed to be important in arousal (wakefullness/alertness); blood pressure regulation; control of mood (low NA=>depression). Where do the NA pathways run?

NA pathways from locus coeruleus & LTA project to cortex, Hippocampus, thalamus, hypothalamus & cerebellum. They do not form succinct contacts, rather being released diffusly

NMMT

There are 4 main dopaminergic pathways. Name these & where the respective cell bodies are located?

Nigrostriatal- substantia nigra


Mesolimbic-VTA


Mesocortical- VTA


Tuberohypphyseal- Hypothal

Seritonin pathways are widespread (similar to NA projections). Where are the nuclei located?

Raphe (midline) nuclei in pons & upper medulla

Seritonin pathways are widespread (similar to NA projections). Where are the nuclei located?

Raphe (midline) nuclei in pons & upper medulla

Serotonin nuclei are located in the Raphe nuclei in pons & upper medulla. What functions are associated with serotonin pathways?

-various behavioural responses (incl hallucinations)


-feeding behaviour


-mood & emotion


-control of sleep/wakefulness


-control of body temp!


-vomiting

Seritonin pathways are widespread (similar to NA projections). Where are the nuclei located?

Raphe (midline) nuclei in pons & upper medulla

Serotonin nuclei are located in the Raphe nuclei in pons & upper medulla. What functions are associated with serotonin pathways?

-various behavioural responses (incl hallucinations)


-feeding behaviour


-mood & emotion


-control of sleep/wakefulness


-control of body temp!


-vomiting

What Neurotransmitter has its main cell bodies located in the Nucleus of meynart (basal frontal cortex)

Ach

Cholinergic Nuclei in the "nucleus of meynard"(Nucleus Basalis-ventral forebrain) project to the cortex. Degeneration of these nuclei is associated with what illness?

Alzheimers disease is associated with the degreneration of cholinergic neurons in the forebrain and specifically the nucleus of meynart.