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10 Cards in this Set

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  • Back
T-cells cause diseases, when they respond to what types of antigens? x5
1. Inappropriate antigen
2. Superantigen
3. Persistent
4. Autoantigen
5. Transplant antigen
Type IV hypersensitivity initiated by what?
CD4+ Th1 T-cells
Type IV hypersensitivity response is regulated by what cells?
Macrophages
T/F - Type IV hypersensitivity requires antibodies.
FALSE
T/F - Superantigens require normal antigen processing.
FALSE
What do superantigens bind to?
V-beta sequences
T/F - Superantigens bind in the peptide-binding cleft.
False
What two things does the Superantigens bridge?
TCR Beta chain V region AND MHC class II alpha chain
Superantigens lead to what type of immune responses? x3
1. Massive T-cell activation
2. Massive cytokine production
3. Shock-like syndromes
What class of bacteria is particularly responsible for superantigens?
Staphylococcus