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10 Cards in this Set
- Front
- Back
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T-cells cause diseases, when they respond to what types of antigens? x5
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1. Inappropriate antigen
2. Superantigen 3. Persistent 4. Autoantigen 5. Transplant antigen |
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Type IV hypersensitivity initiated by what?
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CD4+ Th1 T-cells
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Type IV hypersensitivity response is regulated by what cells?
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Macrophages
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T/F - Type IV hypersensitivity requires antibodies.
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FALSE
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T/F - Superantigens require normal antigen processing.
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FALSE
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What do superantigens bind to?
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V-beta sequences
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T/F - Superantigens bind in the peptide-binding cleft.
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False
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What two things does the Superantigens bridge?
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TCR Beta chain V region AND MHC class II alpha chain
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Superantigens lead to what type of immune responses? x3
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1. Massive T-cell activation
2. Massive cytokine production 3. Shock-like syndromes |
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What class of bacteria is particularly responsible for superantigens?
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Staphylococcus
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