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17 Cards in this Set
- Front
- Back
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All TCR's are associated with what?
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CD3
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Which MHC Class protein is not encoded in MHC?
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MHC Class I Beta microglobulin
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For MHC class I, the antigen binds between what two proteins?
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Alpha 1 and Alpha 2
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For MHC class II, the antigen binds between what two proteins?
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Alpha 1 and Beta 1
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MHC class I is distributed to what kind of cells?
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All nucleated cells
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MHC class II is distributed to what type of cells?
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All APC
Macrophages, dendritic cells, B-cells, and Thymic epithelium. |
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MHC Class I proteins present antigens to?
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CD8 T cells
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MHC Class II proteins present antigens to?
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CD4 T cells
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MHC is on what chromosome?
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Chromosome 6
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What are the regions and gene products of HLA MHC Class I?
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Region A --> HLA-A (alpha chain)
Region B --> HLA-B (alpha chain) Region C --> HLA-C (alpha chain) |
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What are the regions and gene product of HLA MHC class II?
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Region DP --> DP alpha beta
Region DQ --> DQ alpha beta Region DR --> DR alpha beta |
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What does HLA class III encode for?
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Not antigen presenting stuff, but encodes for C proteins and TNF alpha & TNF beta
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MHC Class I pathway processes antigens from where?
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Endogenous
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MHC Class II pathway processes antigens from where?
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Exogenous
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In MHC Class I pathway, the antigen binds to MHC Class I inside what?
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ER
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In MHC Class II pathway, the antigen and MHC bind in what?
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Phagolysosome
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How are MHC genes expressed?
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Co-dominantly (maternal + paternal)
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