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23 Cards in this Set
- Front
- Back
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What is an example of neuromuscular blocker?
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Curare
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What are the two types of neuromuscular blockers?
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1. Competitive agents
2. Depolarizing agents |
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How does tubocurarine block neuromuscular receptor?
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Competitive antagonize
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Give two examples of depolarizing agents.
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Succinylcholine
Decamethonium |
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What is the mechanism of depolarizing agents.
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Depolarize membrane by opening ion channels (just like ACh) followed by a block of neuromuscular transmission.
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What are the physical responses to depolarizing agents.
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Brief muscle fasciculation (muscle twitch)
Followed by flaccid paralysis |
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What are the physical responses to competitive neuromuscular blockers?
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Rapid action (if IV) where
Immediate muscle weakness Followed by total flaccid paralysis |
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Which muscles get effected first with competitive agents?
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Small, rapid muscles such as eyes and fingers
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Ultimately, what happens physiologically with competitive agents?
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Respiration ceases
Intercostal muscles and diaphragm paralyzed |
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Recovery of respiratory function from competitive agents occurs how?
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Reverse order. Diaphragm regains function first
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Muscle soreness follows the administration of what drug and why?
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Succinylcholie due to prolonged depolarization
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T/F - Anesthesia and analgesia is induced by neuromuscular blockers.
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False
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What is the effect on the level of anesthesia with neuromuscular blockers?
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Ligher level of anasthesia
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Neuromuscular blockers are effective in what type of procedures? x2
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Orthapedic and Intubations
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During electroshock therapy, what is the benefit of neuromuscular blockers?
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Prevents trauma
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What is the effect of neuromuscular blockers on the CNS and why?
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None, b/c does not cross blood brain barrier
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How is the autonomic ganglia affected with neuromuscular blockers?
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Competitve agents have some effect with blocking autonomic ganglia
, but not depolarizing agenst |
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Associate neuromuscular blockers with histamine
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Tubocurarine produces histamine release
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What does neuromuscular blockers do to CV system?
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Tubocurarine in large IV doses result in rapid and severe hypotension
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What competes or reverses the effects of COMPETITIVE neuromuscular blockers?
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Cholinesterase inhibitor
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Cholinesterase inhibitors do what to depolarizing agents?
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Enhance effects
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What is the most unwanted side effects of neuromuscular blockers? x3
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1. Apnea (cease of breathing)
2. Cardiovascular collapse 3. Histamine release results |
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Malignant hyperthermia can be treated with what?
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Halothane and succinylcholine
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