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19 Cards in this Set
- Front
- Back
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Choice of immunosuppressive drug depends on what?
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Stage of immune response.
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What are the stages of the immune responses and when do they come into effect?
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1. Primary response (transplantation)
2. Secondary response (autoimmunity) |
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What is IL-2?
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A cytokine that enhances growth and proliferation of the cytotoxic T-cells.
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What are four things that can cause autoimmunity.
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1. Release of self antigens
2. Loss of tolerance 3. Cross reaction with foreign antigen 4. Bystander or Network stimulation |
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Cyclosporin does what three things?
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1. Blocks calcineurin
2. Inhibits T cell activation 3. Inhibits IL-2 production |
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What is the major side effect of cyclosporin?
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Nephrotoxicity
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What are the three effects of Tacrolimus?
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1. Blocks calcineurin
2. Inhibits T-cell activation 3. Inhibits IL-2 production |
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What is the major side effect of Tacrolimus?
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Nephrotoxicity
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Sirolimus does what?
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1. Inhibits target of rapamycin (TOR) pathway
2. Inhibits T-cell activation 3. Inhibits RESPONSE to IL-2 |
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Sirolimus has what major effects.
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hyperlipidemia, HTN, thromboctyopenia
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Glucocorticoids do what? x3
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1. Affects cell proliferation and recirculation
2. Affects lymphocyte activation 3. Reduce Immunoglobulin levels |
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Glucocoriticoids side effects. x5
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1. Cushings like symptoms
2. Hyperglycemia 3. Insomnia 4. Moon Face 5. Emotional lability |
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Azathioprine action
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Blocks purine synthesis
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Azathioprine side effects. x3
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1. Bone marrow suppresion
2. Leukopenia 3. Thrombocytopenia |
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Cyclophosphamide actions
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Alkylates DNA and inhibits cell division
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What is the major side effect of Cyclophosphamide? x3
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1. Hemorrhagic cystitis
2. Bone marrow suppression 3. Cardiotoxicity |
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Methotrexate actions x2
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1. Inhibits Dihydrofolate reductase
2. Inhibits cell proliferation |
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Methotrexate side effects x5
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1. Hepatic fibrosis
2. Increased risk of infection 3. Allopecia 4. Bone marrow depression 5. Cirrhosis |
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Effective SubQ drug for rheumatoid arthritis.
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Etanercept
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