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18 Cards in this Set
- Front
- Back
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On a Rosenthal (Scatchard) Plot, what does the slope imply?
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Affinity
or Inverse of Kd |
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On a Rosenthal (Scatchard) Plot, a curved line implies what?
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More than one receptor site.
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On a Hill plot, a slope of 1 implies what? What is the slope is higher than one?
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If slope = 1, then 1 receptor site.
If slope > 1, then more than 1 receptor site. |
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Supersensitivity results from what? Give example.
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Lack of stimulation.
Denervation supersensitivity of muscle. |
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Overstimulation can lead to what?
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Subsensitivity
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During muscle denervation, the muscle becomes supersensitive to what?
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ACh
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Supersensitivity involved what in tems of receptors? x2
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1. Increased number of receptors.
2. Greater spread of receptors |
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What are the two types of receptors and what are they coupled to?
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1. IONOTROPIC - ion channels
2. METABOTROPIC - metabolic events |
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Which receptors involve G-proteins?
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Metabotropic receptors
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Define First Messengers.
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Chemical released by cell that act on another cell.
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Where are 1st messengers located?
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Extra Cellular Matrix
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First messengers facilitate communication where?
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Between cells
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Second messengers are located where?
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Intracellular
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Second messengers facilitate communication where?
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Within cell
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Adenylyl Cyclase is an example of what kind of receptor?
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Metatropic Receptor
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Arachidonic Acid is the precursor to what lipid mediators (chemical messengers)? x3
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1. Prostaglandins
2. Leukotrienes 3. Thrmboxanes |
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What are the NOS (Nitric Oxide Synthase) subtypes?
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1. nNOS - neuronal (NOS1)
2. iNOS - inducible (NOS2) 3. eNOS - endothelial (NOS3) |
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In macrophages, what does NO react with to kill foreign bodies?
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IFN - gamma
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