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22 Cards in this Set
- Front
- Back
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Define synergistic effect.
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When two or more drugs given simulatneously produce an effect greater than the sum of their individual effects
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Define tachyphylaxis.
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Tolerance after a single exposure.
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Define efficacy.
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Ability of a drug bound to receptor to produce an effect
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Define potency.
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A measure of the concentration of the drug required to elicit an effect.
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1. Similar curve implies similar effects on receptor.
2. ACh more potent |
What does this log curve imply? x2
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What is an agonist in terms of affinity and efficacy?
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With Affinity
With Efficacy |
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What is an antagonist in terms of affinity and efficacy?
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With Affinity
No Efficacy |
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T/F - Antagonist drugs causes conformation change in receptor.
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False - only agonists b/c the conformational change is what causes effect
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T/F - A partial agonist is a partial antagonist.
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True - when partial agonist is in presence with another agonist.
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Define inverse agonists.
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Bind to receptor but have effects that are opposite to those of agonists
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What type of drugs do these drug curves represent?
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Note that this is log curve
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How can antagonism be overcome?
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Increase agonist concentration
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How does the antagonist displace the dose-effect curve of agonist?
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To the right
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What does the antagonist do to the maximal efficacy of agonists?
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Does not change
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What does the antagonist do to the affinity of the agonists.
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Decreases it.
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Competitive antagonist
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What is this an example of?
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Noncompetitive antagonist
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What is this an example of?
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Noncompetitive antagonist bind to what?
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Receptor or associated molecule.
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T/F - Effects of noncompetitive antagonist may be overcome by increasing the agonist concentration.
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False
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What does the noncompetitive antagonist do to the maximal efficacy of agonist drug?
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Decrease it.
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Eq. for Therapeutic indes.
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TI = TD50 / ED50
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Eq. for Certain Safety Factor
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CSF = TD1 / ED99
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