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22 Cards in this Set

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Define synergistic effect.
When two or more drugs given simulatneously produce an effect greater than the sum of their individual effects
Define tachyphylaxis.
Tolerance after a single exposure.
Define efficacy.
Ability of a drug bound to receptor to produce an effect
Define potency.
A measure of the concentration of the drug required to elicit an effect.
1. Similar curve implies similar effects on receptor.
2. ACh more potent
What does this log curve imply? x2
What is an agonist in terms of affinity and efficacy?
With Affinity

With Efficacy
What is an antagonist in terms of affinity and efficacy?
With Affinity

No Efficacy
T/F - Antagonist drugs causes conformation change in receptor.
False - only agonists b/c the conformational change is what causes effect
T/F - A partial agonist is a partial antagonist.
True - when partial agonist is in presence with another agonist.
Define inverse agonists.
Bind to receptor but have effects that are opposite to those of agonists
What type of drugs do these drug curves represent?
Note that this is log curve
How can antagonism be overcome?
Increase agonist concentration
How does the antagonist displace the dose-effect curve of agonist?
To the right
What does the antagonist do to the maximal efficacy of agonists?
Does not change
What does the antagonist do to the affinity of the agonists.
Decreases it.
Competitive antagonist
What is this an example of?
Noncompetitive antagonist
What is this an example of?
Noncompetitive antagonist bind to what?
Receptor or associated molecule.
T/F - Effects of noncompetitive antagonist may be overcome by increasing the agonist concentration.
False
What does the noncompetitive antagonist do to the maximal efficacy of agonist drug?
Decrease it.
Eq. for Therapeutic indes.
TI = TD50 / ED50
Eq. for Certain Safety Factor
CSF = TD1 / ED99