Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
What are the two enzymes associated with salvage pathways.
|
1. Adenosine Phosphoribosyltransferase.
2. HGPRT |
|
|
What is the disorder associated with an absence of HGPRT?
|
Lesch-Nyhan syndrome
|
|
|
What is the general feature of salvage pathways?
|
Transfer of the ribose from PRPP to a nitrogenous base.
|
|
|
What is the reaction catalyzed by adenosine phosphoribosyltransferase?
|
Adenosine + PRPP --> Adenylate + PPi
|
|
|
What is the reaction catalyzed by HGPRT?
|
Hypoxanthine + PRPP --> inosinate + PPi
Guanine + PRPP --> guanylate + PPi |
|
|
Why do primates have high uric acid blood levels?
|
Because they fail to catabolize uric acid.
|
|
|
At physiological pH, uric acid exists as what?
|
MSU (Monosodium Urate)
|
|
|
What are two pathologies associated with Hyperuricemia.
|
Acute Gouty Arthritis
Lithiasis |
|
|
What is the basis of hyperuricemia?
|
1. Increased purine production
2. Increased purine degradation |
|
|
What happens in hyperuricemia when purine production increases?
|
1. Elevated PRPP synthetase levels.
2. Loss of feedback inhibition of PRPP amidotransferases |
|
|
What happens in hyperuricemia when purine degradation goes down.
|
1. Decreased slavage pathway-HGPRT activity is low
2. Increased adenine deaminase activity. |
|
|
What is the treatment for acute gouty arthritis? x 3
|
1. NSAIDS
2. Steroids 3. Colchicine |
|
|
What is the treatment for chronic hyperuricemia? x 2
|
1. Diet
2. Urate lowering drugs |
|
|
What are two examples of urate lowering drugs?
|
1. Allopurinol
2. Uricosurics |
