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24 Cards in this Set
- Front
- Back
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Definition Chlorom?
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solider Tumor von Blasten
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Synonyme Chlorom?
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green cancer
Chlorosarkom myeloid sarcoma |
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Einteilung der Tumoren der hämatopoetischen und lymphatischen Gewebe?
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myeloische Neoplasmen
lymphatische Neoplasmen histiozytäre/ dendritische Neoplasmen |
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Einteilung myeloische Neoplasmen?
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AML
MDS MPN MDS/MPN Syndrome |
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Einteilung MPN?
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CML
PCV (Polycythamia vera) ET (essentielle Thrombozytämie) PMF (primäre Myelofibrose) |
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Einteilung MDS?
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RA (Refraktäre Anämie)
RARS (RA mit Ring-Sideroblasten) RAEB (RA mit Blasten-Exzess) RCMD (refraktäre Zytopenie mit multilineage Dysplasie) |
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Einteilung MDS/MPN Syndrome?
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CMML (chronische myelomonozytäre Leukämie)
juvenile CMML atypische CML, BCR-ABL negativ |
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Einteilung lymphatische Neoplasmen?
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non Hodkin-Lymphome:
precursor lymphatische Neoplasmen reife B-Zell-Neoplasmen reife T-Zell oder NK-Zell-Neoplasmen Hodgkin-Lymphome |
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Phänotyp der Transformation CML in Blastenkrise?
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2/3 myeloischer Phänotyp
1/3 lymphatischer Phänotyp |
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Einteilung reifzellige B-Zell-Neoplasien?
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CLL/SLL (chronische lymphatische Leukämie/ kleinzelliges B-Zell-Lymphom)
Prolymphozyten-Leukämie Marginalzonen-Lymphom Mantelzell-Lymphom diffuses grosszelliges B-Zell-Lymphom follikuläres Lymphom Haarzell-Leukämie Lymphoplasmozytäres Lymphom (Immunozytom) Plasmozytom/ Plasmazell-Lymphom Burkitt-Lymphom |
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Merksatz für (reifzellige) B-Zell-NHL?
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Une FOLLE mit MANTEL, PRO-BURKA, aber nicht IMMUN gegen DIFFUS GROSSEN, HAARAUSFALL in der MARGINALZONE und CHRONISCHEN KNOCHENSCHMERZEN
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overall incidence for lymphoma?
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22/100'000
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overall incidence for leukemia?
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13/100'000
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what are common B cell markers?
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CD19, CD20, CD22
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what is the germinal center marker?
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GC marker is CD10, also known as cALLa
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what are the immunophenotypic findings in Burkitt lymphoma?
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mature B-cells, positive for B cell markers and CD79, negative for TdT staining
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which immunophenotypic finding differentiates Burkitt lymphoma from ALL?
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Burkitt lymphoma is negative for TdT
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what are the characteristics concerning proliferation rate in Burkitt lymphoma?
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rate of proliferation, determined with Ki-67 staining is >= 95%
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what is the prophylactic treatment of tumor lysis?
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bicarbonate hydration and allopurinol or rasburicase = Fasturtec
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what are the principles of therapy for Burkitt lymphoma?
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high doses of alkylating agents with CNS prophylaxis
no radiation therapy |
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what are the three major categories for Burkitt lymphoma?
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1) intensive short-duration chemotherapy
2) ALL-like therapy 3) therapy that includes consolidation with high-dose therapy and ASCT |
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what are chemotherapy regimens for Burkitt lymphoma?
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CODOX/M-IVAC
cyclophosphamide, vincristin, doxorubicin and high-dose methotrexate alternating with ifosfamide, etoposide and high-dose cytarabine along with intrathecal methotrexate and cytarabine ALL-like BEAM carmustine, etoposide, cytarabine and melphalan with ASCT support ALL-like hyper-CVAD cyclophosphamide, vincristine, doxorubicin, dexamethasone |
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which other staging system beside the Ann Arbor staging system is used for Burkitt lymphoma?
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Murphy staging system
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what is the long-term survival in Burkitt lymphoma for pediatric and adult patients?
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60-90% in children
more variable in adults |
