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41 Cards in this Set
- Front
- Back
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What is the immunophenotype for ALL/L?
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Tdt+, B cells with CD 19, CD 10, PAX5; T cells with CD1, CD2, CD5, and CD7
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Which cell can be described as a slightly larger than a lymphocyte with large irregular nucleus, scant cytoplasm and finely stippled chromatin?
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lymphoblast
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What are molecular findings associated with ALL/L?
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hyperploidy (>50 chromosomes); t(12;21); NOTCH 1 mutations (gain); E2A & EBF mutations (loss)
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Which leukemia/lymphomas is associated with t(12;21)
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ALL/L
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What is the IHC for ALL/L?
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MPO negative and PAS positive
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What factors are associated with a worse prognosis for ALL/L?
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< 2y/o; translocations of MLL gene; adolescents or adults; WBC > 100,000; presence of t (9;22)
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What factors are associaed with favorable prognosis for ALL/L?
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2-10 y/o; WBC <100,000; hyperploidy; trisomy 4, 7, & 10 t(12;21)
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What chromosomal translocation is associated with a worse prognosis for ALL/L?
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t(9:22)
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Which chromosomal translocation is associated with a favorable prognosis for ALL/L?
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t(12;21)
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What is the Philadelphia chromosome?
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t(9;22)
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What is the difference between chronic lymphocytic leukemia and small lymphocytic lymphoma?
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difference in numbers of peripheral blood lymphocytosis (CLL = >4000 lymphs/mm3)
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What is the epidemiology for CLL/SLL?
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male predominance; less common in Japan & Asia
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Which type of leukemia/lymphoma is associated with smudge cells?
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CLL/SLL
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What is the immunophenotype for CLL/SLL?
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CD 19, CD 20, CD 23, CD 5, and surface Ig
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What are molecular features for CLL/SLL?
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trisomy 12q
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What molecular factor is associated with worse prognosis for CLL/SLL?
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associated with ZAP-70
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What is the immunophenotype for follicular lymphoma?
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BCL2
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What are molecular factors for follicular lymphoma?
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t(14;18)
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What is the immunophenotype for diffuse large B cell lymphoma?
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B-cell markers
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What are molecular factors associated with diffuse large B cell lymphoma?
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BCL6
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Which lymphoma/leukemia is characterized by starry sky pattern?
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Burkitt's lymphoma
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What is the immunophenotype for Burkitt's lymphoma?
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negative for BCL2
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What molecular factors are associated with Burkitt's lymphoma?
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t(8;14), t(8;2), and t(8;22)
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What is the immunophenotype for mantle cell lyphoma?
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cyclin D1, negative for CD23
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What molecular factors as associated with mantle cell lymphoma?
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t(11;14)
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What molecular factors are associated with marginal zone lymphoma?
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BCL10 and MALT1
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Which lymphoma/leukemia is associated with maltomas?
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marginal zone lymphoma
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What is the immunophenotype for hairy cell leukemia?
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CD11c, CD25, CD103
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Which lymphoma presents with eosinophilia and pruritis?
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peripheral T cell lymphoma
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What are molecular factors associated with anaplastic large cell lymphoma?
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ALK positive; molecular rearrangement of ALK gene on chromosome 2p23 (JAK/STAT)
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Which lymphoma/leukemia has cells with multilobulated cells?
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adult T cell lymphoma/leukemia
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What is the immunophenotype for adult T cell lymphoma/leukemia?
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negative for CD8
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What are molecular factors for adult T cell lymphoma/leukemia?
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clonal HTLV-1 provirus is present
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Which lymphoma/leukemia is associated with HTLV-1?
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adult T cell lymphoma/leukemia
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What are features of mucosis fungoides?
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sezary-lutzner cells, pautrier microabsesses and cerebriform nuclei
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What is the immunophenotype for mucosis fungoides?
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CLA, CCR4, and CCR10
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What is the morphology for large granular lymphocytic leukemia?
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large lymphocytes with abundant blue cytoplasm containing a few coarse azurophilic granules
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What is the immunophenotype for large granular lymphocytic leukemia?
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CD 56; negative for CD 56
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What are characteristics of Felty syndrome and what leukemia/lymphoma is it associated with?
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RA, splenomegaly, neutropenia; large granula lymphocytic leukemia is underlying disorder
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What are molecular features for extranodal NK/T-cell lymphoma?
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EBV episomes in tumor cells
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What is the immunophenotype for extranodal NK/T-cell lymphoma?
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negative for CD 21 and CD3; positive for CD56
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