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17 Cards in this Set
- Front
- Back
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Non-Hodgkins Lymphoma
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B-cell or T-cell
Mostly malignant cells Widespread disease at Dx Waldeyers ring common site Noncontiguous spread Low grade types incurable, high grade types either cured or kill |
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Hodgkins Lymphoma
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Unique R-S cell (CD15 and CD30 +)
Many reactive cells, few malignant cells Localized disease Waldeyers ring rarely involved Predictable contiguous spread Generally curable |
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Follicular pattern is always a ____ lymphoma
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B-cell lymphoma
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Chronic lymphocytic leukemia (CLL)/ Small lymphocytic lymphoma (SLL)
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Most common leukemia monoclonal CD+5,+23
Age ~60, high WBC count with lymphocytosis >4000 and smudge cells (leukemic), generalized lymphadenopathy & hepatosplenomegaly (lymphoma) |
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Most common lymphoma
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Follicular lymphoma, always B-cell CD-10+
Grade 1(small cells)NOT BAD, Grade 2 (mixed small and large cells), Grade 3 (mostly large cells) WORST |
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Diffuse large B-cell lymphoma: Body cavity LCL
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(primary effusion lymphoma): usually in HIV, presents as malignant ascites or pleural effusion, tumor cells always infected with HHV8 (HHV8 also in Kaposi sarcoma, Castleman’s disease)
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Mantle cell lymphoma genetic defect?
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t(11;14)
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Marginal Zone Lymphoma
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Nodal or extranodal, especially stomach, lung, spleen
Also known as MALT lymphoma or BALT Associated with autoimmune or inflammation, may REGRESS if inciting agent is removed e.g., Hashimoto thyroiditis, Sjogren disease Stomach- Helicobacter pylori |
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Burkitt lymphoma genetic defect? pattern seen in lymph nodes?
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t(8;14)
Kids or HIV patients, aggressive, starry sky pattern stars= macrophages, sky=lymphoma |
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T-cell lymphomas
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Not very common in USA
Worse prognosis than B-cell lymphomas Skin involvement is common All have diffuse pattern |
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Precursor-T lymphoblastic lymphoma (T-cell ALL)
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Mediastinal mass, adolescent males
The ONLY Tdt + lymphoma (of course, precursor B-cell leukemia/lymphoma also Tdt +) |
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Anaplastic large cell lymphoma
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ALK gene rearrangements diagnostic, t(2;5)
CD30 + (Ki-1) Anaplastic large cells (duh !!), horseshoe nucleus with lots of cytoplasm = “hallmark” cells |
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Adult T-cell leukemia/lymphoma
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Caused by HTLV-1 (human T-cell leukemia/lymphoma virus 1)
Endemic in Japan, Caribbean basin Skin lesions, lymphadenopathy, lymphocytosis with cloverleaf or floret nucleus, hypercalcemia Usually rapidly fatal |
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Mycosis fungoides/Sezary syndrome
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Cutaneous T-helper CD4 lymphoma
Pautrier microabscess Leukemic phase = Sezary syndrome, associated with generalized exfoliative erythroderma |
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Extranodal NK/T-cell lymphoma
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Nasal type called “lethal midline granuloma”
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Hodgkin lymphoma
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NOT classically B- or T-cell
Characterized by the Reed-Sternberg cell, and variants + CD15 and CD30 Prominent inflammatory background with neutrophils, lymphocytes, eosinophils Patients usually age 20-30 yrs., mediastinal mass Contiguous lymph node spread, then spleen, liver, bone marrow Fever, night sweats, wt. loss, pain after EtOH Usually curable (long term survival carries increased risk for AML, MDS, lung cancer, breast cancer, etc., because of therapy with chemo and radiation) |
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Non-classic Hodgkins
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Lymphocyte predominant (L&H cells, actually a large B-cell lymphoma, CD15 and 30 negative)
not really hodgkins |
