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20 Cards in this Set
- Front
- Back
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Lymphomas can be broken down into Non-Hodgkin and Hodgkin lymphoma. The presence of what type of cell differentiates the two mainly?
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Ree-Sternberg cells, which are large B cells with multilobed nuclei ("owl-eyes"
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No treatment is required for patients lacking symptoms in non-hodgkin lymphoma. But when SHOULD treatment be started?
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Treatment should be started if there is significant organomegaly, anemia, thrombocytopenia, neuropathy, amyloidosis or hyperviscosity. Rituximab is often used.
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In the non-Hodgkin lymphomas, which group is the most common in terms of prevalence?
A. B cell NHL B. T cell NHL |
B cell lymphomas are the most common group of lymphomas (85-90% of all non-Hodgkin Lymphomas)
specifically according to syllabus, Follicular lymphoma |
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What type of lymphoma is described:
Neoplastic proliferation of small B cells that form follicle-like nodules. |
Non-Hodgkin lymphoma: B cell type: Follicular Lymphoma
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What is the genetic translocation for follicular lymphoma and what is the outcome?
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t(14; 18) --> overexpression of BCL2 which inhibits apoptosis
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What is the genetic translocation for follicular lymphoma and the outcome?
A. t (11; 14) --> overexpression of BCL2 which inhibits apoptosis B. t (11; 14) --> juxtaposition of cyclinD1 gene to immunoglobulin heavy chain gene leads to increased expression of cyclin D1 C. t(14;18) --> overexpression of BCL2 which inhibits apoptosis D. t(14;18) --> juxtaposition of cyclinD1 gene to immunoglobulin heavy chain gene leads to increased expression of cyclin D1 |
C. t(14;18) --> overexpression of BCL2 which inhibits apoptosis
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What is the genetic translocation for mantle cell lymphoma and the outcome?
A. t (11; 14) --> overexpression of BCL2 which inhibits apoptosis B. t (11; 14) --> juxtaposition of cyclinD1 gene to immunoglobulin heavy chain gene leads to increased expression of cyclin D1 C. t(14;18) --> overexpression of BCL2 which inhibits apoptosis D. t(14;18) --> juxtaposition of cyclinD1 gene to immunoglobulin heavy chain gene leads to increased expression of cyclin D1 |
B. t (11; 14) --> juxtaposition of cyclinD1 gene to immunoglobulin heavy chain gene leads to increased expression of cyclin D1
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What lymphoma is profiled:
CD19+ , CD5+, CD22+ , CD23 - , t(11;14), treated with R-CHOP A. follicular lymphoma B. mantle cell lymphoma C. marginal zone lymphoma D. small lymphocytic lymphoma / chronic lymphocytic lymphoma |
B. mantle cell lymphoma
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Buriktt Lymphoma is a [ low / intermediate / high ] grade B cell NHL.
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intermediate
Neoplastic proliferation of intermediate sized B cells (CD20+); associated with EBV. t(8;14) , t(2;8) or t(8;22) . Occurs in children AND adults. * background of "starry sky" macrophages * EBV is thought to play an important role in pathogenesis. CD20+ , CD10+, surface immunoglobulin positive |
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What lymphoma presents histologically as a background of "starry sky" macrophages?
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Burkitt Lymphoma
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Two forms of Burkitt's lymphoma exists: endemic and sporadic. Which is associated with Africa and which with increased HIV infection?
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Endemic = Africa ; sporadic = everywhere else in world, and associated with increased incidence in HIV infection
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True or False:
B-cell lymphomas are more aggressive than T-cell lymphomas. |
FALSE. T cell ones tend to be more aggressive!
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Hodgkin lymphoma is broken down into classical and other/non-classical. Which three belong to classical and which to the other? What makes it classical versus not?
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Classical (CD15+, CD30+, CD45-): Nodular sclerosing HL, Mixed cellularity HL, Lymphocyte depletion HL.
Not (CD45+, CD20+, CD15-, CD30-): Lymphocyte predominance HL |
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What are B symptoms and for what kind of lymphoma are these possibly present?
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B symptoms are night sweats, fever, weight loss. B symptoms commonly seen in Hodgkin lymphoma.
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What is described:
* most common form of HL * occurs in young adults * females more than males * patients present with cervical adenopathy and /or mediastinal mass A. Nodular sclerosing HL B. Mixed cellularity HL C. Lymphocyte depletion HL D. Lymphocyte predominance HL |
A. Nodular sclerosing HL
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What is described:
* second most common type of HL * middle aged elderly males A. Nodular sclerosing HL B. Mixed cellularity HL C. Lymphocyte depletion HL D. Lymphocyte predominance HL |
B. Mixed cellularity HL
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Which HL is described:
histologically, lymphocytes are fewer in number, and RS cells may predominate over the reactive component. RS cells can appear bizzare and multinucleated! * fever and peripheral blood cytopenias A. Nodular sclerosing HL B. Mixed cellularity HL C. Lymphocyte depletion HL D. Lymphocyte predominance HL |
C. Lymphocyte depletion HL
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Which HL is described:
histologically, predominant cell is the small lymphocyte. RS are few in number Sometimes these RS cells ar ecalled "popcorn cells". * asymptomatic, just with cervical or axillary adenopathy A. Nodular sclerosing HL B. Mixed cellularity HL C. Lymphocyte depletion HL D. Lymphocyte predominance HL |
D. Lymphocyte predominance HL
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True or False:
Lymphocyte predominance HL usually presents as an asymptomatic patient with cervical or axillary adenopathy. |
TRUE
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What are the CDs on Lymphocyte predominance HL?
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This is a non-classical HL, so it has CD15-, CD30-, CD45+, CD20+
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